Campus Event Calendar
Event Entry
What and Who
Rule-based models for signal transduction - applications and challenges
Heinz Köppl
EPFL, Lausanne
Talk
AG 1, AG 3, AG 4, AG 5, SWS, RG1, MMCI
Public Audience
English
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Date, Time and Location
Thursday, 8 October 2009
11:00
45 Minutes
E1 3 - Hörsaal Gebäude
HS 002
Saarbrücken
Abstract
Transient complex formation and mutual posttranslational modification of proteins in signaling generate a combinatorial number of reachable chemical species. Traditionally, model reduction heuristics have been applied in kinetic modeling to cope with this complexity. Such unprincipled model reductions are prone to be wrong because they are not based on experimental evidence. Exploiting the local context on which many protein-protein interactions are conditioned, rule-based modeling allows to concisely encode, to simulate and to reduce such combinatorial reaction systems. We present our efforts to transform rule-based models into species reaction systems involving a minimal set of abstract species. Furthermore we propose a framework for model reduction and calibration based on metrics between stochastic processes.
Contact
Conny Liegl
30270150
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Conny Liegl, 10/06/2009 15:37
Conny Liegl, 10/06/2009 15:33 -- Created document.
Conny Liegl, 10/06/2009 15:33 -- Created document.