Campus Event Calendar
Event Entry
What and Who
HIV drug resistance and viral fitness
Hauke Walter
Institute of Clinical and Molecular Virology University of Erlangen
Talk
AG 1, AG 2, AG 3, AG 4
MPI Audience
Note: We use this to send email in the morning.
Date, Time and Location
Thursday, 22 May 2003
10:00
60 Minutes
46.1 - MPII
023
Saarbrücken
Abstract
Abstract: HIV is one of the most flexible viruses known in the world. From this
viewpoint it is not astonishing that the virus can develop resistance to all of
the 17 approved antiviral drugs in a very short time, to some drugs in only two
weeks. Viral drug resistances are detectable by functional analyses using labour
intensive recombinant virus assays, and by simple sequencing of the genes
targeted by the respective drugs. However, due to the high variability of HIV
the impact of the mutations found in the genome remains unclear in some cases,
in particular because of extensive interactions. Furthermore, drug resistant HI
viruses have been shown to replicate more poorly and are less infective than the
non-resistant wild type viruses: they are said to be "unfit". These changes have
been shown to be clinically relevant in terms of disease progression already
several years ago. However, a prediction for an individual patient was not yet
possible maybe due to methodological problems. We have developed a new assay to
determine viral fitness and first results will be presented.
viewpoint it is not astonishing that the virus can develop resistance to all of
the 17 approved antiviral drugs in a very short time, to some drugs in only two
weeks. Viral drug resistances are detectable by functional analyses using labour
intensive recombinant virus assays, and by simple sequencing of the genes
targeted by the respective drugs. However, due to the high variability of HIV
the impact of the mutations found in the genome remains unclear in some cases,
in particular because of extensive interactions. Furthermore, drug resistant HI
viruses have been shown to replicate more poorly and are less infective than the
non-resistant wild type viruses: they are said to be "unfit". These changes have
been shown to be clinically relevant in terms of disease progression already
several years ago. However, a prediction for an individual patient was not yet
possible maybe due to methodological problems. We have developed a new assay to
determine viral fitness and first results will be presented.
Contact
Niko Beerenwinkel
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