Campus Event Calendar
Event Entry
New for: D2, D3
What and Who
Progress in Membrane protein bioinformatics.
Prof. Arne Elofsson
Department of Biochemistry & Biophysics, Stockholm University
Talk
AG 1, AG 2, AG 3, AG 4, AG 5, SWS, RG1, MMCI
MPI Audience
English
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Date, Time and Location
Wednesday, 17 November 2010
14:15
60 Minutes
E1 4
024
Saarbrücken
Abstract
Progress in Membrane protein bioinformatics.
Alpha-helical membrane proteins are crucial players in the cell and
crucial in processes ranging from basic small-molecule transport to
sophisticated signaling pathways. During the last few years the number
of known 3D-structured of membrane proteins have increased
significantly. These proteins have shown an unexpected structural
variability and the earlier picture of alpha-helical membrane
proteins to consist of twenty residues long straight helices
connected by short loops has been shown to be incomplete. In addition
the earlier view of a simple two stage folding process consisting of
recognition of the hydrophobic helices followed by packing of them has
also been shown to be incomplete. Here I will review
these two findings as well as discuss implications of these for the
classification and prediction of structural, evolutionary and functional features of
alpha-helical membrane proteins in different genomes.
Alpha-helical membrane proteins are crucial players in the cell and
crucial in processes ranging from basic small-molecule transport to
sophisticated signaling pathways. During the last few years the number
of known 3D-structured of membrane proteins have increased
significantly. These proteins have shown an unexpected structural
variability and the earlier picture of alpha-helical membrane
proteins to consist of twenty residues long straight helices
connected by short loops has been shown to be incomplete. In addition
the earlier view of a simple two stage folding process consisting of
recognition of the hydrophobic helices followed by packing of them has
also been shown to be incomplete. Here I will review
these two findings as well as discuss implications of these for the
classification and prediction of structural, evolutionary and functional features of
alpha-helical membrane proteins in different genomes.
Contact
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Ruth Schneppen-Christmann, 11/11/2010 14:12 -- Created document.