Campus Event Calendar
Event Entry
What and Who
From fitness landscapes to seascapes: Non-equilibrium dynamics of selection and adaption
Ville Mustonen
University of Cologne
Talk
AG 1, AG 3, AG 4, AG 5, SWS, RG1, MMCI
Public Audience
English
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Date, Time and Location
Wednesday, 11 March 2009
11:15
45 Minutes
E1 4
024
Saarbrücken
Abstract
Evolution is a quest for innovation. Organisms evolve new phenotypes to adapt to changing natural selection. Can we read this dynamics in genomic sequences? Not every mutation under positive selection responds to a change in selection: beneficial changes also occur at evolutionary equilibrium, repairing previous deleterious changes and restoring existing functions.
Adaptation, in contrast, is viewed here as a genuine non-equilibrium phenomenon: the genomic response to time-dependent selection. Our approach extends the static concept of fitness landscapes to dynamic fitness seascapes. It shows that adaptation requires a surplus of beneficial substitutions over deleterious ones.
We discuss the evolution of yeast and Drosophila genomes, providing examples where adaptive evolution can and where it cannot be inferred, despite the presence of positive selection.
Contact
Conny Liegl
302-70150
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Conny Liegl, 03/09/2009 13:57 -- Created document.