This thesis contributes one of the first steps towards a better understanding of such concerns in the presence of data manipulation. From the point of view of user's privacy, we show the inefficacy of common obfuscation methods like face blurring, and propose more advanced techniques based on head inpainting and adversarial examples. We discuss the duality of model security and user privacy problems and describe the implications of research in one area for the other. Finally, we study the knowledge aspect of the data manipulation problem: the more one knows about the target model, the more effective manipulations one can craft. We propose a game theoretic framework to systematically represent the partial knowledge on the target model and derive privacy and security guarantees. We also demonstrate that one can reveal architectural details and training hyperparameters of a model only by querying it, leading to even more effective data manipulations against it.