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What and Who
Title:A hybrid moment closure approach to stochastic chemical kinetics
Speaker:Verena Wolf
coming from:Fachrichtung Informatik - Saarbrücken
Speakers Bio:
Event Type:Joint Lecture Series
Visibility:D1, D2, D3, D4, D5, SWS, RG1, MMCI
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Level:Public Audience
Date, Time and Location
Date:Wednesday, 2 April 2014
Duration:60 Minutes
Building:E1 5
Stochastic modeling of biochemically reacting systems is an important
branch of quantitative systems biology. Stochastic simulation is in
widespread use for analyzing such models, but it is computationally
expensive and only provides estimates that are subject to statistical
uncertainty. Recently fast numerical simulation methods have been
developed which are based on a moment representation of the underlying
probability distribution.
In this talk I will present a hybrid scheme for the fast numerical
simulation of such models which uses a moment representation only for
the distribution of chemical species that are present in high copy
numbers. The distribution of the remaining small molecular populations
are obtained via the integration of the corresponding chemical master
equation. Based on a number of case studies I will show that the
approach is accurate and very efficient and thus suitable for
computationally expensive tasks such as the estimation of kinetic
Name(s):Jennifer Müller
EMail:--email address not disclosed on the web
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Attachments, File(s):
  • Jennifer Müller, 03/26/2014 02:33 PM
  • Jennifer Müller, 03/26/2014 02:17 PM -- Created document.