Campus Event Calendar
Event Entry
New for: D1, D2, D3, D4, D5
What and Who
Whole Genome Sequencing, Comparative Genomics, and Systems Biology*
Prof. Dr. Gene Myers, Ph.D.
Faculty of Computer Science, University of California, Berkeley
Talk
AG 1, AG 2, AG 3, AG 4, AG 5
MPI Audience
Note: We use this to send email in the morning.
Date, Time and Location
Wednesday, 2 March 2005
17:00
-- Not specified --
46.1 - MPII
024
Saarbrücken
Abstract
The whole-genome shotgun sequencing method with paired end-reads has
proven rapid
and economical, producing high-quality reconstructions of Drosophila
(2000), Human (2001)
and Mouse (2001), in quick succession. We discuss the overall
algorithmic strategy,
and the results one can expect by comparing the whole genome assembly of
Drosophila
against the recently finished sequence, and advances such as
high-density solid state
sequencing and single molecule detection systems.
We anticipate having the euchromatic portions of the genomes of twelve
species
of Drosophila in the next year. We discuss the current state of the art
in comparative
gene finding, cis-control module finding, and possible improvements.
The hope of these approaches is that we will be able to accurately identify
the “parts lists” of the D. melanogaster genome, a basic prerequisite
for systems biology.
We conclude with a segment on the possibility of a program of
high-throughput in-situ image
analysis in Drosophila embryos. We describe what information we might
collect and
what we might be able to infer form it. It is our contention that this
may be the best
way to understand development from a systems perspective.
proven rapid
and economical, producing high-quality reconstructions of Drosophila
(2000), Human (2001)
and Mouse (2001), in quick succession. We discuss the overall
algorithmic strategy,
and the results one can expect by comparing the whole genome assembly of
Drosophila
against the recently finished sequence, and advances such as
high-density solid state
sequencing and single molecule detection systems.
We anticipate having the euchromatic portions of the genomes of twelve
species
of Drosophila in the next year. We discuss the current state of the art
in comparative
gene finding, cis-control module finding, and possible improvements.
The hope of these approaches is that we will be able to accurately identify
the “parts lists” of the D. melanogaster genome, a basic prerequisite
for systems biology.
We conclude with a segment on the possibility of a program of
high-throughput in-situ image
analysis in Drosophila embryos. We describe what information we might
collect and
what we might be able to infer form it. It is our contention that this
may be the best
way to understand development from a systems perspective.
Contact
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logged in users only
Ruth Schneppen-Christmann, 03/02/2005 08:28
Ruth Schneppen-Christmann, 02/28/2005 15:28
Ruth Schneppen-Christmann, 02/28/2005 15:27 -- Created document.
Ruth Schneppen-Christmann, 02/28/2005 15:28
Ruth Schneppen-Christmann, 02/28/2005 15:27 -- Created document.