Campus Event Calendar
Event Entry
What and Who
Hepatitis C Virus Proteins as Targets for Drug Development: The role of Bioinformatics and Modelling
Prof. Anna Tramontano
University of Rome "La Sapienza" Department of Biochemical Sciences "Rossi Fanelli"
Talk
AG 1, AG 2, AG 3, AG 4
MPI Audience
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Date, Time and Location
Thursday, 8 May 2003
16:00
60 Minutes
46.1 - MPII
021
Saarbrücken
Abstract
Hepatitis C virus (HCV), a member of the Flaviviridae family, has been
recognised to be
responsible for both parenterally transmitted and sporadic non-A and non-B
hepatitis affecting 1-3% of the world population. HCV is a positive stranded
RNA virus encoding a single polyprotein which contains at least ten unique
structural and non-structural proteins. Amongst these the structural protein
E2 has been of special interest for vaccine development and the serine
protease NS3, which is responsible for cleavage of the polyprotein, for the
development of small molecule inhibitors. I will focus on the contribution
of computational techniques and the use of structural information for the
design and discovery of novel therapeutic agents for these targets.
Both drug discovery and vaccine design efforts will be discussed taking into
account also the problem of emerging resistance.
recognised to be
responsible for both parenterally transmitted and sporadic non-A and non-B
hepatitis affecting 1-3% of the world population. HCV is a positive stranded
RNA virus encoding a single polyprotein which contains at least ten unique
structural and non-structural proteins. Amongst these the structural protein
E2 has been of special interest for vaccine development and the serine
protease NS3, which is responsible for cleavage of the polyprotein, for the
development of small molecule inhibitors. I will focus on the contribution
of computational techniques and the use of structural information for the
design and discovery of novel therapeutic agents for these targets.
Both drug discovery and vaccine design efforts will be discussed taking into
account also the problem of emerging resistance.
Contact
Ruth Schneppen-Christmann
303
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