Campus Event Calendar
Event Entry
What and Who
System-oriented modeling of Saccharomyces cerevisiae: couping cell cycle progression and energy metabolism
Prof. Dr. Matthias Reuss
Institut für Verfahrenstechnik Universität Stuttgart
Talk
AG 1, AG 2, AG 3, AG 4
MPI Audience
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Date, Time and Location
Wednesday, 2 July 2003
17:00
-- Not specified --
46.1 - MPII
024
Saarbrücken
Abstract
Baker´s yeast currently represents the best characterized eucaryotic organism and thus serves as an important model system in systems biology. The lecture is aimed at presenting an integrated model describing the coordination of yeast cell growth and proliferation. The second messenger cyclic AMP (cAMP) plays a central role in this context, since cAMP influences both energy metabolism and cell cycle progression via a protein kinase A-dependent signalling cascade. Experiments have been performed in synchronous and continuous yeast cultures to quantitatively asses cAMP cell cycle dynamics and its regulatory effects on energy metabolism. These results are incorporated into a rigorous mathematical model comprising mutually interlinked submodels for metabolism (glycolysis and storage carbohydrates), cell growth, cell cycle progress, and cAMP signal transduction. The integrated single cell modell yields a dynamic description of the cAMP-dependent regulation of metabolism and cell cycle progression during the different cell cycle phases. The chosen modular approach is potentially transferable to systems of medical importance such as models of tumor behaviour. Moreover, the model can also serve as basis for a segregated description of heterogenous cell populations, e.g. in bioreactors.
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