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Event Entry
What and Who
A study on relevance of G-Quadruplex DNA in recombinogenic regions
Prithvi Mani
University of Madras, India
PhD Application Talk
AG 1, AG 3, AG 4, AG 5, SWS, RG1, MMCI
Public Audience
English
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Date, Time and Location
Tuesday, 14 July 2009
09:00
240 Minutes
E1 4
024
Saarbrücken
Abstract
Identifying non-B DNA structures relevance in several critical functions of Human genome has been an enigma for several decades. One such structure which is the crux of those investigations is G-Quadruplex DNA. Presence of G-Quadruplex DNA in telomeres, promoters and close proximity with proto-oncogenes has generated interest as possible drug target. This raises the interesting possibility of DNA sequence and/or other cis- elements as determinants of recombination. My computational analyses have revealed that recombination hotspots harbor significantly higher number of G-Quadruplex DNA than the recombination coldspots. Several supporting elements in this regard provide us an opportunity to decipher the role of non-canonical sequences in formation of non-B DNA structure with involvement in recombination along with multitude of cellular factors.
Contact
IMPRS Office Team
0681 9325 225
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Stephanie Jörg, 07/08/2009 12:20 -- Created document.