Campus Event Calendar
Event Entry
What and Who
Translational Control: Non-Coding RNAs and Alternative Splicing
Prof. Dr. Rolf Backofen
University of Freiburg, Dep. of CS, Bioinformatics
AG3 Talk
AG 1, AG 2, AG 3, AG 4, AG 5, SWS, RG1, RG2
Public Audience
English
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Date, Time and Location
Monday, 21 January 2008
15:00
60 Minutes
E1 4
024
Saarbrücken
Abstract
In the past years, the common view of RNA has evolved from a more or less
boring intermediate in protein translation to a very important player
in cell regulation. The changed role was primarily the result of the
detection of thousands of non-coding RNAs with many different regulatory
functions in post-translational regulation.
The detection of new functional RNAs requires new comparative methods
for motif detection since the RNA sequence is much less conserved than
the RNA
structure. Hence, purely sequence-based methods for finding
RNA-motifs such as multiple sequence alignment will fail, and
we will discuss various approach (e.g. MARNA, LocaRNA) to sequence-structure
alignment developed in our group.
Another important aspect of translation control is alternative
splicing. In the second part of the talk, we will concentrate on
modulation of alternative splicing and discuss the importance of RNA
structure in this regulation.
boring intermediate in protein translation to a very important player
in cell regulation. The changed role was primarily the result of the
detection of thousands of non-coding RNAs with many different regulatory
functions in post-translational regulation.
The detection of new functional RNAs requires new comparative methods
for motif detection since the RNA sequence is much less conserved than
the RNA
structure. Hence, purely sequence-based methods for finding
RNA-motifs such as multiple sequence alignment will fail, and
we will discuss various approach (e.g. MARNA, LocaRNA) to sequence-structure
alignment developed in our group.
Another important aspect of translation control is alternative
splicing. In the second part of the talk, we will concentrate on
modulation of alternative splicing and discuss the importance of RNA
structure in this regulation.
Contact
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Ruth Schneppen-Christmann, 01/16/2008 12:10 -- Created document.