Campus Event Calendar
Event Entry
What and Who
A hybrid moment closure approach to stochastic chemical kinetics
Verena Wolf
Fachrichtung Informatik - Saarbrücken
Joint Lecture Series
AG 1, AG 2, AG 3, AG 4, AG 5, SWS, RG1, MMCI
Public Audience
English
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Date, Time and Location
Wednesday, 2 April 2014
12:15
60 Minutes
E1 5
002
Saarbrücken
Abstract
Stochastic modeling of biochemically reacting systems is an important
branch of quantitative systems biology. Stochastic simulation is in
widespread use for analyzing such models, but it is computationally
expensive and only provides estimates that are subject to statistical
uncertainty. Recently fast numerical simulation methods have been
developed which are based on a moment representation of the underlying
probability distribution.
In this talk I will present a hybrid scheme for the fast numerical
simulation of such models which uses a moment representation only for
the distribution of chemical species that are present in high copy
numbers. The distribution of the remaining small molecular populations
are obtained via the integration of the corresponding chemical master
equation. Based on a number of case studies I will show that the
approach is accurate and very efficient and thus suitable for
computationally expensive tasks such as the estimation of kinetic
constants.
branch of quantitative systems biology. Stochastic simulation is in
widespread use for analyzing such models, but it is computationally
expensive and only provides estimates that are subject to statistical
uncertainty. Recently fast numerical simulation methods have been
developed which are based on a moment representation of the underlying
probability distribution.
In this talk I will present a hybrid scheme for the fast numerical
simulation of such models which uses a moment representation only for
the distribution of chemical species that are present in high copy
numbers. The distribution of the remaining small molecular populations
are obtained via the integration of the corresponding chemical master
equation. Based on a number of case studies I will show that the
approach is accurate and very efficient and thus suitable for
computationally expensive tasks such as the estimation of kinetic
constants.
Contact
Jennifer Müller
2900
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Jennifer Müller, 03/26/2014 14:33
Jennifer Müller, 03/26/2014 14:17 -- Created document.
Jennifer Müller, 03/26/2014 14:17 -- Created document.