| ECCB 2002 Poster sorted by: Author | Number Next | Previous poster (in order of the view you have selected) |
Title: A linear theory of optimal regulation relates gene expression to function | P92 |
Liebermeister, Wolfram; Schuster, Stefan; Heinrich, Reinhard lieberme@molgen.mpg.de MPI fuer Molekulare Genetik, Berlin |
| We investigate an optimality-based model of regulatory systems. According to this model, systems show a linear reaction to perturbations, and the behaviour of regulators is related to their function, i.e their influence on the relevant variables. This optimal behaviour can be realized by a causal feedback model. Assuming that the concept applies to explain gene expression data, we test predictions concerning knock-out experiments and simulate the correlated expression of metabolic genes. |
|