Hahn, Andreas(1);Costello, Christine(2);Lu, Tim(2);Lengauer, Thomas(3);Schreiber, Stefan(2) - Expression Analysis in Inflammatory Bowel Disease

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Title: Expression Analysis in Inflammatory Bowel Disease

P54

Hahn, Andreas(1); Costello, Christine(2); Lu, Tim(2); Lengauer, Thomas(3); Schreiber, Stefan(2)

Andreas.Hahn@scai.fraunhofer.de
(1) Fraunhofer-Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven, D-53754 Sankt Augustin, Germany
(2) 1st Department of Medicine, Christian-Albrechts-University Kiel, Schittenhelmstrasse 12, D -24105 Kiel, Germany
(3) Max-Planck-Institute for Informatics, Stuhlsatzenhausweg 85, D-66123 Saarbrücken, Germany

Inflammatory bowel disease comes in two forms: Crohn's disease and ulcerative colitis. Both of them are genetically complex, but are also influenced by environmental factors and have increasing prevalence and incidence. The two forms of the disease are of high interest, because until now very few is known about their aetiology. After the finding of NOD2 as an important gene for developing Crohn's disease, we analysed expression data of 33 persons and 35000 clones. Normalization and comparison of the expression levels of three groups of persons with different disease status (normal, Crohn's disease, and ulerative colitis) were conducted. We present new candidate genes and give some functional explanation of their influence to the disease.

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