Your search returned the following 32 documents:

32. Docking Analysis and Resistance Evaluation of Clinically Relevant Mutations Associated with the HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors Nevirapine, Efavirenz and Etravirine
    Stefano Alcaro, Claudia Alteri, Anna Artese, Francesca Ceccherini-Silberstein, Giosuè Costa, Francesco Ortuso, Federica Forbici, Maria Mercedes Santoro, Lucia Parrotta, Philippe Flandre, Diane Descamps, Vincent Calvez, Anne-Genevieve Marcelin, Carlo Federico Perno, Tobias Sing, and Valentina Svicher
    ChemMedChem 6 (12): 2203-2213, 2011
    
31. Advantages of Predicted Phenotypes and Statistical Learning Models in Inferring Virological Response to Antiretroviral Therapy from HIV Genotype
    André Altmann, Tobias Sing, Hans Vermeiren, Bart Winters, Elke Van Craenenbroeck, Koen Van der Borght, Soo-Yon Rhee, Robert W. Shafer, Eugen Schülter, Rolf Kaiser, Yardena Peres, Anders Sönnerborg, W. Jeffrey Fessel, Francesca Incardona, Maurizio Zazzi, Lee Bacheler, Hermann Van Vlijmen, and Thomas Lengauer
    Antiviral Therapy 14 (2): 273-283, 2009
    
30. Dynamics of NRTI resistance mutations during therapy interruption
    Maria Trignetti, Tobias Sing, Valentina Svicher, Maria Mercedes Santoro, Federica Forbici, Roberta D'Arrigo, Maria Concetta Bellocchi, Mario Santoro, Patrizia Marconi, Mauro Zaccarelli, Maria Paola Trotta, Rita Bellagamba, Pasquale Narciso, Andrea Antinori, Thomas Lengauer, Carlo Federico Perno, and Francesca Ceccherini-Silberstein
    AIDS Research and Human Retroviruses 25 (1): 57-64, 2009
    
29. Molecular Dynamics and Free Energy Studies on the Wild-Type and Mutated HIV-1 Protease Complexed with Four Approved Drugs: Mechanism of Binding and
    Stefano Alcaro, Anna Artese, Francesca Ceccherini-Silberstein, Francesca Ortuso, Carlo Federico Perno, Tobias Sing, and Valentina Svicher
    Journal of Chemical Information and Modeling 49 (7): 1751-1761, 2009
    
28. Model-Based Anti HIV Therapy
    Tobias Sing
    Doctoral dissertation, Universität des Saarlandes, 2008
    
27. Characterization and structural analysis of novel mutations in human immunodeficiency virus type 1 reverse transcriptase involved in the regulation of restistance to nonnucleoside inhibitors
    Francesca Ceccherini-Silberstein, Valentina Svicher, Tobias Sing, Anna Artese, Maria Mercedes Santoro, Federica Forbici, Ada Bertoli, Stefano Alcaro, Guido Palamara, Antonella d'Arminio Monforte, Jan Balzarini, Andrea Antinori, Thomas Lengauer, and Carlo Federico Perno
    Journal of Virology 81 (20): 11507-11519, 2007
    
    
26. Current V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates
    Andrew J. Low, Winnie Dong, Dennison Chan, Tobias Sing, Ronald Swanstrom, Mark Jensen, Satish Pillai, Benjamin Good, and P. Richard Harrigan
    AIDS 21 (14): F19-F26, 2007
    
25. Determining human immunodeficiency virus coreceptor use in a clinical setting: Degree of correlation between two phenotypic assays and a bioinformatic model
    Katharina Skrabal, Andrew J. Low, Winnie Dong, Tobias Sing, Peter K. Cheung, Fabrizio Mammano, and P. Richard Harrigan
    Journal of Clinical Microbiology 45 (2): 279-284, 2007
    
    
24. Fifteen years of env C2V3C3 evolution in six individuals clonally infected with human immunodeficiency virus type 1
    Bernd Kupfer, Tobias Sing, Peter Schüffler, Rabea Hall, Ralf Kurz, Astrid McKeown, Karl-Eduard Schneweis, Wolfgang Eberl, Johannes Oldenburg, Hans H. Brackmann, Jürgen K. Rockstroh, Ulrich Spengler, Martin Däumer, Rolf Kaiser, Thomas Lengauer, and Bertfried Matz
    Journal of Medical Virology 79 (11): 1629-1639, 2007
    
23. Improved prediction of response to antiretroviral combination therapy using the genetic barrier to drug resistance
    Andre Altmann, Niko Beerenwinkel, Tobias Sing, Igor Savenkov, Martin Däumer, Rolf Kaiser, Soo-Yon Rhee, W Jeffrey Fessel, Robert W Shafer, and Thomas Lengauer
    Antiviral Therapy 12 (2): 169-178, 2007
    
22. Inferring virological response from genotype: with or without predicted phenotypes?
    Andre Altmann, Tobias Sing, Hans Vermeiren, Bart Winters, Elke Van Craenenbroeck, Koen Van der Borght, Soo-Yon Rhee, Robert W Shafer, Eugen Schülter, Rolf Kaiser, Yardena Peres, Anders Sonnerborg, W Jeffrey Fessel, Francesca Incardona, Maurizio Zazzi, Lee Bacheler, Hermann Van Vlijmen, and Thomas Lengauer
    In: Proceedings of the 16th International HIV Drug Resistance Workshop, Barbados, Barbados, 2007, S169 p.
    
21. Mutagenetic tree Fisher kernel improves prediction of HIV drug resistance from viral genotype
    Tobias Sing and Niko Beerenwinkel
    In: Advances in Neural Information Processing Systems 19, Vancouver, B.C., Canada, 2007, 1-9
    [PDF: Download: SingNIPS2006.pdf]
    
20. Predicting HIV coreceptor usage on the basis of genetic and clinical covariates
    Tobias Sing, Andrew J. Low, Niko Beerenwinkel, Oliver Sander, Peter K. Cheung, Francisco S. Domingues, Joachim Büch, Martin Däumer, Rolf Kaiser, Thomas Lengauer, and P. Richard Harrigan
    Antiviral Therapy 12 (7): 1097-1106, 2007
    
19. Structural Descriptors of gp120 V3 Loop for the Prediction of HIV-1 Coreceptor Usage
    Oliver Sander, Tobias Sing, Ingolf Sommer, Andrew J. Low, Peter K. Cheung, P. Richard Harrigan, Thomas Lengauer, and Francisco S. Domingues
    PLoS Computational Biology 3 (3): 555-564, 2007
    [PDF: Download: Sander.pdf]
    
18. Validation of geno2pheno and THEO on a large independent clinical dataset
    Andre Altmann, Martin Däumer, Tobias Sing, Niko Beerenwinkel, Hauke Walter, Rolf Kaiser, and Thomas Lengauer
    In: Proceedings of the 5th European HIV Drug Resistance Workshop, Cascais, Portugal, 2007
    
17. EuResist: exploration of multiple modeling techniques for prediction of response to treatment
    Maurizio Zazzi, Ehud Aharoni, Andre Altmann, Fulop Baszó, Penny Bidgood, Gabór Borgulya, J Denholm-Prince, M Fielder, Rolf Kaiser, Carmel Kent, Thomas Lengauer, T Nepusz, Hanni Neuvirth, Yardena Peres, Andrea Petroczi, Mattia Prosperi, L Romano, Michal Rosen-Zvi, Eugen Schülter, Tobias Sing, Andras Sonnerborg, R Thompson, G Ulivi, L Zalány, and Francesca Incardona
    In: Proceedings of the 5th European HIV Drug Resistance Workshop, Cascais, Portugal, 2007
    
16. Arevir: A Secure Platform for Designing Personalized Antiretroviral Therapies Against HIV
    Kirsten Roomp, Niko Beerenwinkel, Tobias Sing, Eugen Schülter, Joachim Büch, Saleta Sierra-Aragon, Martin Däumer, Daniel Hoffmann, Rolf Kaiser, Thomas Lengauer, and Joachim Selbig
    Lecture Notes in Computer Science 4075: 185-194, 2006
    
15. Bioinformatics-assisted anti-HIV therapy
    Thomas Lengauer and Tobias Sing
    Nature Reviews Microbiology 4: 790-797, 2006
    
14. Compensatory mutations at the HIV cleavage sites p7/p1 and p1/p6-gag in therapy-naive and therapy-experienced patients
    Jens Verheyen, Elena Litau, Tobias Sing, Martin Däumer, Melanie Balduin, Mark Oette, Gerd Fätkenheuer, Jürgen K. Rockstroh, Ulrike Schuldenzucker, Daniel Hoffmann, Herbert Pfister, and Rolf Kaiser
    Antiviral Therapy 11 (7): 879-887, 2006
    
13. Involvement of novel HIV-1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors
    Valentina Svicher, Tobias Sing, Maria Mercedes Santoro, Federica Forbici, Fátima Rodriguez- Barrios, Ada Bertoli, Niko Beerenwinkel, Maria Concetta Bellocchi, Federigo Gago, Antonella d´Arminio Monforte, Andrea Antinori, Thomas Lengauer, Francesca Ceccherini-Silberstein, and Carlo-Federico Perno
    Journal of Virology 80 (14): 7186-7198, 2006
    
12. Stable coreceptor usage of HIV in patients with ongoing treatment failure on HAART
    Clara Lehmann, Martin Däumer, Ibrahim Bousaad, Tobias Sing, Niko Beerenwinkel, Thomas Lengauer, Norbert Schmeisser, Christoph Wyen, Gerd Fätkenheuer, and Rolf Kaiser
    Journal of Clinical Virology 37 (4): 300-304, 2006
    
11. ROCR: Visualizing classifier performance in R
    Tobias Sing, Oliver Sander, Niko Beerenwinkel, and Thomas Lengauer
    Bioinformatics 21 (20): 3940-3941, 2006
    
10. A highly ordered network of HIV-1 RT mutations regulates the continuous escape from antiviral drugs
    Valentina Svicher, Francesca Ceccherini-Silberstein, Tobias Sing, Maria Mercedes Santoro, C. Gori, Niko Beerenwinkel, F. Gago, R. D'Arrigo, M.C. Bellochi, S. Giannella, A. Bertoli, A. D'Arminio Monforte, A. Antinori, and Carlo-Federico Perno
    In: International Workshop in HIV Dynamics and Evolution, Cleveland, Ohio, USA, 2005
    
9. Additional Mutations in HIV-1 Reverse Transcriptase are Involved in the Highly Ordered Regulation of NRTI Resistance
   Valentina Svicher, Francesca Ceccherini-Silberstein, Tobias Sing, Maria Mercedes Santoro, C. Gori, Niko Beerenwinkel, F. Gago, R. D'Arrigo, M. C. Bellocchi, S. Giannella, A. Bertoli, A. D'Arminio Monforte, A. Antinori, and Carlo-Federico Perno
   In: Proceedings of the 3rd European HIV Drug Resistance Workshop, Athens, Greece, 2005
   
8. Characterization of novel HIV Drug Resistance Mutations using clustering, multidimensional scaling and SVM-based feature ranking
   Tobias Sing, Valentina Svicher, Niko Beerenwinkel, Francesca Ceccherini-Silberstein, Martin Däumer, Rolf Kaiser, Hauke Walter, Klaus Korn, Daniel Hoffmann, Mark Oette, Jürgen K. Rockstroh, Gerd Fätkenheuer, Carlo-Federico Perno, and Thomas Lengauer
   In: Knowledge Discovery in Databases: PKDD 2005., Porto, Portugal, 2005, 285-296
   
7. Computational methods for the design of effective therapies against drug resistant HIV strains
   Niko Beerenwinkel, Tobias Sing, Thomas Lengauer, Jörg Rahnenführer, Kirsten Roomp, Igor Savenkov, Roman Fischer, Daniel Hoffmann, Joachim Selbig, Klaus Korn, Hauke Walter, Thomas Berg, Patrick Braun, Gerd Fätkenheuer, Mark Oette, Jürgen Rockstroh, Bernd Kupfer, Rolf Kaiser, and Martin Däumer
   Bioinformatics 21 (21): 3943-3950, 2005
   
6. Estimating HIV evolutionary pathways and the genetic barrier to drug resistance
   Niko Beerenwinkel, Martin Däumer, Tobias Sing, Jörg Rahnenführer, Thomas Lengauer, Joachim Selbig, Daniel Hoffmann, and Rolf Kaiser
   The Journal of Infectious Diseases 191 (11): 1953-1960, 2005
   
5. Geno2pheno[coreceptor]: a tool for predicting coreceptor usage from genotype and for monitoring coreceptor-associated sequence alterations
   Tobias Sing, Niko Beerenwinkel, Rolf Kaiser, Daniel Hoffmann, Martin Däumer, and Thomas Lengauer
   In: Proceedings of the 3rd European HIV Drug Resistance Workshop, Athens, Greece, 2005
   
4. Stable coreceptor usage of HIV-1 in patients with ongoing treatment failure on HAART
   Rolf Kaiser, Ibo Boussaad, C. Lehmann, Martin Däumer, Tobias Sing, N. Schmeisser, C. Wyen, and Gerd Fätkenheuer
   In: Proceedings of the 3rd European HIV Drug Resistance Workshop, Athens, Greece, 2005
   
3. Computing the genetic barrier
   Niko Beerenwinkel, Tobias Sing, Martin Däumer, Rolf Kaiser, and Thomas Lengauer
   In: XII International HIV Drug resistance Workshop, Tenerife, Spain, 2004, S125-S125
   
2. Learning localized rule mixtures by maximizing the area under the ROC curve, with an application to the prediction of HIV-1 coreceptor usage
   Tobias Sing
   Master's thesis, Universität Freiburg, 2004
   
1. Learning mixtures of localized rules by maximizing the area under the ROC curve
   Tobias Sing, Niko Beerenwinkel, and Thomas Lengauer
   In: ROCAI-2004: 1st International Workshop on ROC Analysis in Artificial Intelligence, Valencia, Spain, 2004, 89-96