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Proceedings Article, Paper
@InProceedings
Beitrag in Tagungsband, Workshop

Author, Editor
Author(s):
Schlicker, Andreas
Huthmacher, Carola
Ramírez, Fidel
Lengauer, Thomas
Albrecht, Mario
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Editor(s):
Huson, Daniel
Kohlbacher, Oliver
Lupas, Andrei
Nieselt, Kay
Zell, Andreas
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dblp
dblp
dblp
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Not MPII Editor(s):
Huson, Daniel
Kohlbacher, Oliver
Lupas, Andrei
Nieselt, Kay
Zell, Andreas
BibTeX cite key*:
Albrecht2006h
Title, Booktitle
Title*:
Functional evaluation of domain-domain interactions and human protein interaction networks
Booktitle*:
German Conference on Bioinformatics (GCB 2006)
Event, URLs
Conference URL::
http://www.gcb2006.de/
Downloading URL:
Event Address*:
Tübingen, Germany
Language:
English
Event Date*
(no longer used):
Organization:
Gesellschaft fuer Informatik (GI)
Event Start Date:
19 September 2006
Event End Date:
22 September 2006
Publisher
Name*:
Gesellschaft für Informatik
URL:
http://www.gi-ev.de/service/publikationen/lni/
Address*:
Bonn, Germany
Type:
Vol, No, Year, pp.
Series:
Lecture Notes in Informatics
Volume:
P-83
Number:
Month:
September
Pages:
115-126
Year*:
2006
VG Wort Pages:
ISBN/ISSN:
978-3-88579-177-5; ISSN 1617-5468
Sequence Number:
DOI:
Note, Abstract, ©
(LaTeX) Abstract:
Large amounts of protein and domain interaction data are being
produced by experimental high-throughput techniques and computational
approaches. To gain insight into the value of the provided data, we used our new
similarity measure based on the Gene Ontology to evaluate the molecular functions
and biological processes of interacting proteins or domains. The applied measure
particularly addresses the frequent annotation of proteins or domains with multiple
Gene Ontology terms. Using our similarity measure, we compare predicted
domain-domain and human protein-protein interactions with experimentally
derived interactions. The results show that our similarity measure is of significant
benefit in quality assessment and confidence ranking of domain and protein
networks. We also derive useful confidence score thresholds for dividing domain
interaction predictions into subsets of low and high confidence.
Keywords:
Bioinformatics, Protein-Protein Interaction, Domain-Domain Interaction, Semantic Similarity, Confidence Value
HyperLinks / References / URLs:
http://www.gi-ev.de/fileadmin/redaktion/2006_LNI/LNI-P-83.pdf
Download
Access Level:
Intranet

Correlation
MPG Unit:
Max-Planck-Institut für Informatik
MPG Subunit:
Computational Biology and Applied Algorithmics
Audience:
popular
Appearance:
MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort



BibTeX Entry:

@INPROCEEDINGS{Albrecht2006h,
AUTHOR = {Schlicker, Andreas and Huthmacher, Carola and Ram{\'i}rez, Fidel and Lengauer, Thomas and Albrecht, Mario},
EDITOR = {Huson, Daniel and Kohlbacher, Oliver and Lupas, Andrei and Nieselt, Kay and Zell, Andreas},
TITLE = {Functional evaluation of domain-domain interactions and human protein interaction networks},
BOOKTITLE = {German Conference on Bioinformatics (GCB 2006)},
PUBLISHER = {Gesellschaft für Informatik},
YEAR = {2006},
ORGANIZATION = {Gesellschaft fuer Informatik (GI)},
VOLUME = {P-83},
PAGES = {115--126},
SERIES = {Lecture Notes in Informatics},
ADDRESS = {T{\"u}bingen, Germany},
MONTH = {September},
ISBN = {978-3-88579-177-5},
; ISBN = {ISSN 1617-5468},
}


Entry last modified by Mario Albrecht, 03/20/2007
Hide details for Edit History (please click the blue arrow to see the details)Edit History (please click the blue arrow to see the details)

Editor(s)
Andreas Schlicker
Created
09/27/2006 02:35:17 PM
Revisions
9.
8.
7.
6.
5.
Editor(s)
Mario Albrecht
Christine Kiesel
Christine Kiesel
Christine Kiesel
Christine Kiesel
Edit Dates
03/20/2007 07:55:49 PM
22.02.2007 15:31:04
22.02.2007 15:10:59
22.02.2007 15:00:41
21/02/2007 11:11:32