MPI-INF D3 Publications: Journal Article: Stable coreceptor usage of {HIV} in patients with ongoing treatment failure on {HAART}

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Author, Editor(s)

Author(s):

Lehmann, Clara
Däumer, Martin
Bousaad, Ibrahim
Sing, Tobias
Beerenwinkel, Niko
Lengauer, Thomas
Schmeisser, Norbert
Wyen, Christoph
Fätkenheuer, Gerd
Kaiser, Rolf

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Not MPG Author(s):

Lehmann, Clara
Däumer, Martin
Bousaad, Ibrahim
Beerenwinkel, Niko
Schmeisser, Norbert
Wyen, Christoph
Fätkenheuer, Gerd
Kaiser, Rolf

BibTeX cite key*:

Lengauer2006g

Title

Title*:

Stable coreceptor usage of HIV in patients with ongoing treatment failure on HAART

Journal

Journal Title*:	Journal of Clinical Virology	Journal's URL:
Download URL for the article:	http://dx.doi.org/10.1016/j.jcv.2006.08.008	Language:	English

Publisher

Publisher's Name:	Elsevier	Publisher's URL:
Publisher's Address:	Amsterdam, The Netherlands	ISSN:	1386-6532

Vol, No, pp, Date

Volume*:	37	Number:	4
Publishing Date:	2006
Pages*:	300-304	Number of VG Pages:
Page Start:		Page End:
Sequence Number:		DOI:	10.1016/j.jcv.2006.08.008

Note, Abstract, ©

Note:
(LaTeX) Abstract:	Background Disease progression in HIV infection has been associated with switch of viral coreceptor usage from CCR5 to CXCR4. Objectives To investigate the relationship between HIV-coreceptor tropism and clinical and virological outcome in 40 heavily pretreated patients over time. Methods Coreceptor phenotype was predicted after sequencing the V3 loop of the HIV glycoprotein 120. Results Coreceptor use was stable during observation time in 87% of patients, and CCR5 tropism was predominant. Viral mutations in the pol gene and clinical parameters were not predictive for coreceptor switching. Conclusions Even in patients with repeated HAART failure, CCR5 antagonists might be a valuable treatment option.
URL for the Abstract:	http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VJV-4M04JGS-1&_user=43521&_coverDate=12%2F31%2F2006&_rdoc=14&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236104%232006%23999629995%23636612%23FLA%23display%23Volume)&_cdi=6104&_sort=d&_docanchor=&view=c&_ct=21&_acct=C000004638&_version=1&_urlVersion=0&_userid=43521&md5=e8eac48c07b446e01898a1c55540814c
Categories, Keywords:	HIV, Chemokine receptors, Virus tropism, HAART failure, Resistance
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Audience:	Expert
Appearance:	MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort

BibTeX Entry:

@ARTICLE{Lengauer2006g,
AUTHOR = {Lehmann, Clara and D{\"a}umer, Martin and Bousaad, Ibrahim and Sing, Tobias and Beerenwinkel, Niko and Lengauer, Thomas and Schmeisser, Norbert and Wyen, Christoph and F{\"a}tkenheuer, Gerd and Kaiser, Rolf},
TITLE = {Stable coreceptor usage of {HIV} in patients with ongoing treatment failure on {HAART}},
JOURNAL = {Journal of Clinical Virology},
PUBLISHER = {Elsevier},
YEAR = {2006},
NUMBER = {4},
VOLUME = {37},
PAGES = {300--304},
ADDRESS = {Amsterdam, The Netherlands},
ISBN = {1386-6532},
DOI = {10.1016/j.jcv.2006.08.008},
}

Entry last modified by Anja Becker, 02/13/2008

Edit History (please click the blue arrow to see the details)

	Editor(s) Ruth Schneppen-Christmann	Created 01/10/2007 10:01:17
Revisions 4. 3. 2. 1. 0.	Editor(s) Anja Becker Ruth Schneppen-Christmann Christine Kiesel Ruth Schneppen-Christmann Ruth Schneppen-Christmann	Edit Dates 13.02.2008 16:16:16 05.03.2007 08:20:39 20.02.2007 17:31:03 15.02.2007 10:16:02 10.01.2007 10:05:43

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