MPI-INF D3 Publications: Journal Article: Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality

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Author(s):

Zotenko, Elena
Mestre, Julian
O'Leary, Dianne
Przytycka, Teresa

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Not MPG Author(s):

O'Leary, Dianne
Przytycka, Teresa

BibTeX cite key*:

Zotenko2008

Title

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Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality

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Journal Title*:	PLoS Computational Biology	Journal's URL:
Download URL for the article:		Language:	English

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Vol, No, pp, Date

Volume*:	4	Number:	8
Publishing Date:	August 2008
Pages*:	e1000140	Number of VG Pages:
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Sequence Number:		DOI:	10.1371/journal.pcbi.1000140

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(LaTeX) Abstract:	The \emph{centrality-lethality rule}, which notes that high-degree nodes in a protein interaction network tend to correspond to proteins that are essential, suggests that the topological prominence of a protein in a protein interaction network may be a good predictor of its biological importance. Even though the correlation between degree and essentiality was confirmed by many independent studies, the reason for this correlation remains illusive. Several hypotheses about putative connections between essentiality of hubs and the topology of protein–protein interaction networks have been proposed, but as we demonstrate, these explanations are not supported by the properties of protein interaction networks. To identify the main topological determinant of essentiality and to provide a biological explanation for the connection between the network topology and essentiality, we performed a rigorous analysis of six variants of the genomewide protein interaction network for Saccharomyces cerevisiae obtained using different techniques. We demonstrated that the majority of hubs are essential due to their involvement in Essential Complex Biological Modules, a group of densely connected proteins with shared biological function that are enriched in essential proteins. Moreover, we rejected two previously proposed explanations for the centrality-lethality rule, one relating the essentiality of hubs to their role in the overall network connectivity and another relying on the recently published essential protein interactions model.
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MPG Unit:	Max-Planck-Institut für Informatik

MPG Subunit:	Computational Biology and Applied Algorithmics
Audience:	experts only
Appearance:	MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort

BibTeX Entry:

@ARTICLE{Zotenko2008,
AUTHOR = {Zotenko, Elena and Mestre, Julian and O'Leary, Dianne and Przytycka, Teresa},
TITLE = {Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality},
JOURNAL = {PLoS Computational Biology},
YEAR = {2008},
NUMBER = {8},
VOLUME = {4},
PAGES = {e1000140},
MONTH = {August},
DOI = {10.1371/journal.pcbi.1000140},
}

Entry last modified by Elena Zotenko, 03/03/2009

Edit History (please click the blue arrow to see the details)

	Editor(s) Elena Zotenko	Created 12/03/2008 17:09:05
Revision 0.	Editor Elena Zotenko	Edit Date 12/03/2008 05:09:05 PM