MPI-INF D3 Publications: Journal Article: Grey and white matter proportional relationships in the cerebellar vermis altered in schizophrenia

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Author, Editor(s)

Author(s):

Lawyer, Glenn
Nesvåg, Ragnar
Varnäs, Katarina
Okugawa, Gaku
Agartz, Ingrid

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Not MPG Author(s):

Lawyer, Glenn
Nesvåg, Ragnar
Varnäs, Katarina
Okugawa, Gaku
Agartz, Ingrid

BibTeX cite key*:

Lawyer2009_cerebellum

Title

Title*:

Grey and white matter proportional relationships in the cerebellar vermis altered in schizophrenia

Journal

Journal Title*:	Cerebellum	Journal's URL:
Download URL for the article:	http://dx.doi.org/10.1007/s12311-008-0071-7	Language:	English

Publisher

Publisher's Name:	Springer	Publisher's URL:
Publisher's Address:	New York, NY	ISSN:	1473-4222

Vol, No, pp, Date

Volume*:	8	Number:	1
Publishing Date:	March 2009
Pages*:	52-60	Number of VG Pages:
Page Start:	52	Page End:	60
Sequence Number:		DOI:	10.1007/s12311-008-0071-7

Note:
(LaTeX) Abstract:	Magnetic resonance imaging studies frequently report abnormalities of the cerebellar vermis in schizophrenia, though with some discrepancies as to the nature and location of such abnormalities. Imaging studies typically investigate volumetric differences between groups. Yet substantial evidence supports the hypothesis that grey and white matter proportions in the mammalian brain are controlled by scaling relationships. If strong proportional relationships between grey and white matter tissue volumes are observed in the healthy vermis, then disturbances to these proportions might characterize vermian dysmorphology in schizophrenia. Measures of grey and white matter tissue volumes from three anatomical divisions of the vermis were obtained from 52 patients with chronic schizophrenia and 55 healthy controls. Cross-correlations of the tissue class volumes were computed for each subject group, controlling for age. The number of significant correlations in each group were compared. In addition, the grey/white matter ratio was computed within and across each vermian division. Differences in mean and variance were assessed using t and F tests. A false discovery rate of 0.05 controlled for multiple comparisons. Among controls, 11 of 15 correlations were significant. Among patients, eight of 15 correlations were significant. Five of the nine grey/white matter ratios had an increased mean in the patient group, and all of the variances were trend level or significantly increased in the patients. Tissue class volumes in the cerebellar vermis were strongly interrelated in controls. These relationships were disturbed in patients with schizophrenia.
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Download Access Level:	Internal

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MPG Unit:	Max-Planck-Institut für Informatik

MPG Subunit:	Computational Biology and Applied Algorithmics
Appearance:	MPII WWW Server, MPII FTP Server, university publications list, working group publication list, Fachbeirat, VG Wort

BibTeX Entry:

@ARTICLE{Lawyer2009_cerebellum,
AUTHOR = {Lawyer, Glenn and Nesvåg, Ragnar and Varn{\"a}s, Katarina and Okugawa, Gaku and Agartz, Ingrid},
TITLE = {Grey and white matter proportional relationships in the cerebellar vermis altered in schizophrenia},
JOURNAL = {Cerebellum},
PUBLISHER = {Springer},
YEAR = {2009},
NUMBER = {1},
VOLUME = {8},
PAGES = {52--60},
ADDRESS = {New York, NY},
MONTH = {March},
ISBN = {1473-4222},
DOI = {10.1007/s12311-008-0071-7},
}

Entry last modified by Anja Becker, 03/11/2010

Edit History (please click the blue arrow to see the details)

	Editor(s) [Library]	Created 01/12/2010 10:03:52
Revisions 2. 1. 0.	Editor(s) Anja Becker Anja Becker Glenn Lawyer	Edit Dates 11.03.2010 14:39:06 11.03.2010 14:38:31 01/12/2010 10:03:52 AM