Journal Article
@Article
Artikel in Fachzeitschrift

Show entries of:

this year (2023) | last year (2022) | two years ago (2021) | Notes URL

Action:

login to update
Options:








Author, Editor(s)
Author(s):
Salamat-Miller, Nazila
Fang, Jianwen
Seidel, Christopher W.
Smalter, Aaron M.
Assenov, Yassen
Albrecht, Mario
Middaugh, C. Russell		dblp
dblp
dblp
dblp
dblp
dblp
dblp
Not MPG Author(s):
Salamat-Miller, Nazila
Fang, Jianwen
Seidel, Christopher W.
Smalter, Aaron M.
Assenov, Yassen
Middaugh, C. Russell

BibTeX cite key*:

Albrecht2006g

Title

Title*:

A network-based analysis of polyanion-binding proteins utilizing yeast protein arrays

Journal

Journal Title*:

Molecular and Cellular Proteomics
Journal's URL:


Download URL
for the article:

http://dx.doi.org/10.1074/mcp.M600240-MCP200
Language:

English

Publisher

Publisher's
Name:

American Society for Biochemistry and Molecular Biology
Publisher's URL:


Publisher's
Address:

Bethesda, MD, USA
ISSN:

1535-9476

Vol, No, pp, Date

Volume*:

5
Number:

12

Publishing Date:

2006

Pages*:

2263-2278
Number of
VG Pages:


Page Start:


Page End:


Sequence Number:


DOI:

10.1074/mcp.M600240-MCP200

Note, Abstract, ©

Note:


(LaTeX) Abstract:

The high affinity of certain cellular polyanions for many proteins (polyanion-binding proteins (PABPs)) has been demonstrated previously. It has been hypothesized that such polyanions may be involved in protein structure stabilization, stimulation of folding through chaperone-like activity, and intra- and extracellular protein transport as well as intracellular organization. The purpose of the proteomics studies reported here was to seek evidence for the idea that the nonspecific but high affinity interactions of PABPs with polyanions have a functional role in intracellular processes. Utilizing yeast protein arrays and five biotinylated cellular polyanion probes (actin, tubulin, heparin, heparan sulfate, and DNA), we identified proteins that interact with these probes and analyzed their structural and amino acid sequence requirements as well as their predicted functions in the yeast proteome. We also provide evidence for the existence of a network-like system for PABPs and their potential roles as critical hubs in intracellular behavior. This investigation takes a first step toward achieving a better understanding of the nature of polyanion-protein interactions within cells and introduces an alternative way of thinking about intracellular organization.

URL for the Abstract:

http://www.mcponline.org/cgi/content/abstract/5/12/2263

Categories,
Keywords:


HyperLinks / References / URLs:


Copyright Message:


Personal Comments:


Download
Access Level:

Intranet

Correlation
MPG Unit:
MPG Subunit:
Appearance:
MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort


BibTeX Entry:

@ARTICLE{Albrecht2006g,
AUTHOR = {Salamat-Miller, Nazila and Fang, Jianwen and Seidel, Christopher W. and Smalter, Aaron M. and Assenov, Yassen and Albrecht, Mario and Middaugh, C. Russell},
 TITLE = {A network-based analysis of polyanion-binding proteins utilizing yeast protein arrays},
 JOURNAL = {Molecular and Cellular Proteomics},
 PUBLISHER = {American Society for Biochemistry and Molecular Biology},
 YEAR = {2006},
 NUMBER = {12},
 VOLUME = {5},
 PAGES = {2263--2278},
 ADDRESS = {Bethesda, MD, USA},
 ISBN = {1535-9476},
 DOI = {10.1074/mcp.M600240-MCP200},
}

Entry last modified by Anja Becker, 02/14/2008
Show details for Edit History (please click the blue arrow to see the details)Edit History (please click the blue arrow to see the details)
Hide details for Edit History (please click the blue arrow to see the details)Edit History (please click the blue arrow to see the details)

Editor(s)
Mario Albrecht		Created
12/01/2006 19:12:19
Revisions
6.
5.
4.
3.
2.		Editor(s)
Anja Becker
Uwe Brahm
Christine Kiesel
Christine Kiesel
Christine Kiesel		Edit Dates
14.02.2008 14:42:42
2007-07-11 12:29:33
22.02.2007 14:54:19
22.02.2007 06:47:22
12/26/2006 07:52:01 PM