MPI-INF D3 Publications: Journal Article: Functional evaluation of domain-domain interactions and human protein interaction networks

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Author, Editor(s)

Author(s):

Schlicker, Andreas
Huthmacher, Carola
Ramírez, Fidel
Lengauer, Thomas
Albrecht, Mario

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BibTeX cite key*:

Albrecht2007g

Title

Title*:

Functional evaluation of domain-domain interactions and human protein interaction networks

Journal

Journal Title*:	Bioinformatics	Journal's URL:	http://bioinformatics.oxfordjournals.org/
Download URL for the article:	http://dx.doi.org/10.1093/bioinformatics/btm012	Language:	English

Publisher

Publisher's Name:	Oxford University Press	Publisher's URL:	http://www.oxfordjournals.org/
Publisher's Address:	Oxford, UK	ISSN:	1367-4803

Vol, No, pp, Date

Volume*:	23	Number:	7
Publishing Date:	2007
Pages*:	859-865	Number of VG Pages:
Page Start:		Page End:
Sequence Number:		DOI:	10.1093/bioinformatics/btm012

Note:
(LaTeX) Abstract:	Motivation: Large amounts of protein and domain interaction data are being produced by experimental high-throughput techniques and computational approaches. To gain insight into the value of the provided data, we used our new similarity measure based on the Gene Ontology (GO) to evaluate the molecular functions and biological processes of interacting proteins or domains. The applied measure particularly addresses the frequent annotation of proteins or domains with multiple GO terms. Results: Using our similarity measure, we compare predicted domain–domain and human protein–protein interactions with experimentally derived interactions. The results show that our similarity measure is of significant benefit in quality assessment and confidence ranking of domain and protein networks. We also derive useful confidence score thresholds for dividing domain interaction predictions into subsets of low and high confidence.
URL for the Abstract:	http://bioinformatics.oxfordjournals.org/cgi/content/abstract/23/7/859
Categories, Keywords:	Bioinformatics, DDI, PPI, Domain-Domain Interactions, Protein-Protein Interactions, Functional Similarity
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Download Access Level:	Intranet

Correlation

MPG Unit:	Max-Planck-Institut für Informatik

MPG Subunit:	Computational Biology and Applied Algorithmics
Audience:	popular
Appearance:	MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort

BibTeX Entry:

@ARTICLE{Albrecht2007g,
AUTHOR = {Schlicker, Andreas and Huthmacher, Carola and Ram{\'i}rez, Fidel and Lengauer, Thomas and Albrecht, Mario},
TITLE = {Functional evaluation of domain-domain interactions and human protein interaction networks},
JOURNAL = {Bioinformatics},
PUBLISHER = {Oxford University Press},
YEAR = {2007},
NUMBER = {7},
VOLUME = {23},
PAGES = {859--865},
ADDRESS = {Oxford, UK},
ISBN = {1367-4803},
DOI = {10.1093/bioinformatics/btm012},
}

Entry last modified by Mario Albrecht, 05/08/2009

Edit History (please click the blue arrow to see the details)

	Editor(s) Andreas Schlicker	Created 04/30/2007 11:07:08
Revisions 5. 4. 3. 2. 1.	Editor(s) Mario Albrecht Mario Albrecht Uwe Brahm Anja Becker Anja Becker	Edit Dates 05/08/2009 07:30:23 PM 03/23/2009 02:41:14 PM 02/28/2008 04:19:45 PM 15.02.2008 08:33:12 01.07.2007 14:21:27