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Title: PRODORIC: Prokaryotic Database Of Gene Regulation
P111
Münch, Richard; Hiller, Karsten; Schobert, Max; Wingender, Edgar; Jahn, Dieter

r.muench@tu-bs.de, d.jahn@tu-bs.de
Institut für Mikrobiologie, Technische Universität Braunschweig, 38106 Braunschweig, Germany

The PRODORIC database systematically organizes information about prokaryotic gene expression, and integrates it into regulatory networks. The initial version focuses on data from pathogenic bacteria like Pseudomonas aeruginosa. PRODORIC connects environmental stimuli with trans-acting transcription factors, cis-acting promoter elements and regulon definition. Especially for the future understanding and modeling of the fine-tuned bacterial pathogen-host interaction, it is necessary to store the existing knowledge in a structured database and to develop tools for the modeling of the prokaryote-eukaryote-crosstalk. Clickable graphic representations of operon, gene and promoter structures including regulator binding sites, transcriptional and translational start sites, supplemented with information about regulatory proteins, are available at various detailed levels. The provided data collection is based on exhaustive analysis of scientific literature, computational sequence prediction and high-throughput data derived from inhouse proteomics/genomics experiments. For the analysis and prediction of regulator binding sites in promoter sequences we implemented tools that allow the scanning of sequence data for putative binding motifs in promoter sequences or even whole genomes.
This integrated approach enables to consider various levels of regulatory networks and adjust predicted data with experimental data. The PRODORIC database is accessible on the World Wide Web at http://prodoric.tu-bs.de.