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Author, Editor(s)

Author(s):

Salamat-Miller, Nazila
Fang, Jianwen
Seidel, Christopher W.
Smalter, Aaron M.
Assenov, Yassen
Albrecht, Mario
Middaugh, C. Russell
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Not MPG Author(s):

Salamat-Miller, Nazila
Fang, Jianwen
Seidel, Christopher W.
Smalter, Aaron M.
Assenov, Yassen
Middaugh, C. Russell

BibTeX cite key*:

Albrecht2006g

Title

Title*:

A network-based analysis of polyanion-binding proteins utilizing yeast protein arrays

Journal

Journal Title*:

Molecular and Cellular Proteomics
Journal's URL:


Download URL
for the article:

http://dx.doi.org/10.1074/mcp.M600240-MCP200
Language:

English

Publisher

Publisher's
Name:

American Society for Biochemistry and Molecular Biology
Publisher's URL:


Publisher's
Address:

Bethesda, MD, USA
ISSN:

1535-9476

Vol, No, pp, Date

Volume*:

5
Number:

12

Publishing Date:

2006

Pages*:

2263-2278
Number of
VG Pages:


Page Start:


Page End:


Sequence Number:


DOI:

10.1074/mcp.M600240-MCP200

Note, Abstract, ©

Note:


(LaTeX) Abstract:

The high affinity of certain cellular polyanions for many proteins (polyanion-binding proteins (PABPs)) has been demonstrated previously. It has been hypothesized that such polyanions may be involved in protein structure stabilization, stimulation of folding through chaperone-like activity, and intra- and extracellular protein transport as well as intracellular organization. The purpose of the proteomics studies reported here was to seek evidence for the idea that the nonspecific but high affinity interactions of PABPs with polyanions have a functional role in intracellular processes. Utilizing yeast protein arrays and five biotinylated cellular polyanion probes (actin, tubulin, heparin, heparan sulfate, and DNA), we identified proteins that interact with these probes and analyzed their structural and amino acid sequence requirements as well as their predicted functions in the yeast proteome. We also provide evidence for the existence of a network-like system for PABPs and their potential roles as critical hubs in intracellular behavior. This investigation takes a first step toward achieving a better understanding of the nature of polyanion-protein interactions within cells and introduces an alternative way of thinking about intracellular organization.

URL for the Abstract:

http://www.mcponline.org/cgi/content/abstract/5/12/2263

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Keywords:


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BibTeX Entry:

@ARTICLE{Albrecht2006g,
AUTHOR = {Salamat-Miller, Nazila and Fang, Jianwen and Seidel, Christopher W. and Smalter, Aaron M. and Assenov, Yassen and Albrecht, Mario and Middaugh, C. Russell},
 TITLE = {A network-based analysis of polyanion-binding proteins utilizing yeast protein arrays},
 JOURNAL = {Molecular and Cellular Proteomics},
 PUBLISHER = {American Society for Biochemistry and Molecular Biology},
 YEAR = {2006},
 NUMBER = {12},
 VOLUME = {5},
 PAGES = {2263--2278},
 ADDRESS = {Bethesda, MD, USA},
 ISBN = {1535-9476},
 DOI = {10.1074/mcp.M600240-MCP200},
}

Entry last modified by Anja Becker, 02/14/2008
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