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Author, Editor(s)

Author(s):

Fernandez, Agustin F.
Assenov, Yassen
Martin-Subero, Jose Ignacio
Balint, Balazs
Siebert, Reiner
Taniguchi, Hiroaki
Yamamoto, Hiroyuki
Hidalgo, Manuel
Tan, Aik-Choon
Galm, Oliver
Ferrer, Isidre
Sanchez-Cespedes, Montse
Villanueva, Alberto
Carmona, Javier
Sanchez-Mut, Jose V.
Berdasco, Maria
Moreno, Victor
Capella, Gabriel
Monk, David
Ballestar, Esteban
Ropero, Santiago
Martinez, Ramon
Sanchez-Carbayo, Marta
Prosper, Felipe
Agirre, Xabier
Fraga, Mario F.
Gran˜a, Osvaldo
Perez-Jurado, Luis
Mora, Jaume
Puig, Susana
Prat, Jaime
Badimon, Lina
Puca, Annibale A.
Meltzer, Stephen J.
Lengauer, Thomas
Bridgewater, John
Bock, Christoph
Esteller, Manel

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Not MPG Author(s):

Fernandez, Agustin F.
Martin-Subero, Jose Ignacio
Balint, Balazs
Siebert, Reiner
Taniguchi, Hiroaki
Yamamoto, Hiroyuki
Hidalgo, Manuel
Tan, Aik-Choon
Galm, Oliver
Ferrer, Isidre
Sanchez-Cespedes, Montse
Villanueva, Alberto
Carmona, Javier
Sanchez-Mut, Jose V.
Berdasco, Maria
Moreno, Victor
Capella, Gabriel
Monk, David
Ballestar, Esteban
Ropero, Santiago
Martinez, Ramon
Sanchez-Carbayo, Marta
Prosper, Felipe
Agirre, Xabier
Fraga, Mario F.
Gran˜a, Osvaldo
Perez-Jurado, Luis
Mora, Jaume
Puig, Susana
Prat, Jaime
Badimon, Lina
Puca, Annibale A.
Meltzer, Stephen J.
Bridgewater, John
Esteller, Manel

BibTeX cite key*:

AssenovGenomeRes2011

Title

Title*:

A DNA methylation fingerprint of 1628 human samples

Journal

Journal Title*:

Genome Research

Journal's URL:

http://genome.cshlp.org/

Download URL
for the article:

http://dx.doi.org/:10.1101/gr.119867.110

Language:

English

Publisher

Publisher's
Name:

Cold Spring Harbor Laboratory Press

Publisher's URL:

http://www.cshlpress.com/

Publisher's
Address:

New York, NY

ISSN:

1088-9051

Vol, No, pp, Date

Volume*:

22

Number:

2

Publishing Date:

2012

Pages*:

407-419

Number of
VG Pages:


Page Start:

407

Page End:

419

Sequence Number:


DOI:

10.1101/gr.119867.110

Note, Abstract, ©

Note:

PMID: 21613409

(LaTeX) Abstract:

Most of the studies characterizing DNA methylation patterns have been restricted to particular genomic loci in a limited number of human samples and pathological conditions. Herein, we present a compromise between an extremely comprehensive study of a human sample population with an intermediate level of resolution of CpGs at the genomic level. We obtained a DNA methylation fingerprint of 1628 human samples in which we interrogated 1505 CpG sites. The DNA methylation patterns revealed show this epigenetic mark to be critical in tissue-type definition and stemness, particularly around transcription start sites that are not within a CpG island. For disease, the generated DNA methylation fingerprints show that, during tumorigenesis, human cancer cells underwent a progressive gain of promoter CpG-island hypermethylation and a loss of CpG methylation in non-CpG-island promoters. Although transformed cells are those in which DNA methylation disruption is more obvious, we observed that other common human diseases, such as neurological and autoimmune disorders, had their own distinct DNA methylation profiles. Most importantly, we provide proof of principle that the DNA methylation fingerprints obtained might be useful for translational purposes by showing that we are able to identify the tumor type origin of cancers of unknown primary origin (CUPs). Thus, the DNA methylation patterns identified across the largest spectrum of samples, tissues, and diseases reported to date constitute a baseline for developing higher-resolution DNA methylation maps and provide important clues concerning the contribution of CpG methylation to tissue identity and its changes in the most prevalent human diseases.

URL for the Abstract:

http://genome.cshlp.org/content/early/2011/07/12/gr.119867.110.abstract

Categories,
Keywords:


HyperLinks / References / URLs:

http://genome.cshlp.org/lookup/doi/10.1101/gr.119867.110

Copyright Message:

Copyright © 2011 by Cold Spring Harbor Laboratory Press

Personal Comments:


Download
Access Level:

Internal

Correlation

MPG Unit:

Max-Planck-Institut für Informatik



MPG Subunit:

Computational Biology and Applied Algorithmics

MPG Subsubunit:

Computational Epigenetics

Research Context:

CANCERDIP

Appearance:

MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort


BibTeX Entry:

@ARTICLE{AssenovGenomeRes2011,
AUTHOR = {Fernandez, Agustin F. and Assenov, Yassen and Martin-Subero, Jose Ignacio and Balint, Balazs and Siebert, Reiner and Taniguchi, Hiroaki and Yamamoto, Hiroyuki and Hidalgo, Manuel and Tan, Aik-Choon and Galm, Oliver and Ferrer, Isidre and Sanchez-Cespedes, Montse and Villanueva, Alberto and Carmona, Javier and Sanchez-Mut, Jose V. and Berdasco, Maria and Moreno, Victor and Capella, Gabriel and Monk, David and Ballestar, Esteban and Ropero, Santiago and Martinez, Ramon and Sanchez-Carbayo, Marta and Prosper, Felipe and Agirre, Xabier and Fraga, Mario F. and Gran˜a, Osvaldo and Perez-Jurado, Luis and Mora, Jaume and Puig, Susana and Prat, Jaime and Badimon, Lina and Puca, Annibale A. and Meltzer, Stephen J. and Lengauer, Thomas and Bridgewater, John and Bock, Christoph and Esteller, Manel},
TITLE = {A {DNA} methylation fingerprint of 1628 human samples},
JOURNAL = {Genome Research},
PUBLISHER = {Cold Spring Harbor Laboratory Press},
YEAR = {2012},
NUMBER = {2},
VOLUME = {22},
PAGES = {407--419},
ADDRESS = {New York, NY},
ISBN = {1088-9051},
DOI = {10.1101/gr.119867.110},
NOTE = {PMID: 21613409},
}


Entry last modified by Anja Becker, 02/12/2013
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