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Author, Editor(s)

Author(s):

Hampe, Jochen
Franke, Andre
Rosenstiel, Philip
Till, Andreas
Teuber, Markus
Huse, Klaus
Albrecht, Mario
Mayr, Gabriele
De La Vega, Francisco M.
Briggs, Jason
Günther, Simone
Prescott, Natalie J.
Onnie, Clive M.
Häsler, Robert
Sipos, Bence
Fölsch, Ulrich R.
Lengauer, Thomas
Platzer, Matthias
Mathew, Christopher G.
Krawczak, Michael
Schreiber, Stefan

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Not MPG Author(s):

Hampe, Jochen
Franke, Andre
Rosenstiel, Philip
Till, Andreas
Teuber, Markus
Huse, Klaus
De La Vega, Francisco M.
Briggs, Jason
Günther, Simone
Prescott, Natalie J.
Onnie, Clive M.
Häsler, Robert
Sipos, Bence
Fölsch, Ulrich R.
Platzer, Matthias
Mathew, Christopher G.
Krawczak, Michael
Schreiber, Stefan

BibTeX cite key*:

Albrecht2007a

Title

Title*:

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Journal

Journal Title*:

Nature Genetics

Journal's URL:


Download URL
for the article:

http://www.nature.com/ng/journal/v39/n2/full/ng1954.html

Language:

English

Publisher

Publisher's
Name:


Publisher's URL:


Publisher's
Address:


ISSN:


Vol, No, pp, Date

Volume*:

39

Number:

2

Publishing Date:

2007

Pages*:

207-211

Number of
VG Pages:

5

Page Start:

207

Page End:

211

Sequence Number:


DOI:


Note, Abstract, ©

Note:


(LaTeX) Abstract:

We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were informative. We followed up on all 72 SNPs with P less than or equal to0.01 with an allele-based disease association test in 380 independent Crohn disease trios, 498 Crohn disease singleton cases and 1,032 controls. Disease association of rs2241880 in the autophagy-related 16-like 1 gene (ATG16L1) was replicated in these samples (P = 4.0 times10-8) and confirmed in a UK case-control sample (P = 0.0004). By haplotype and regression analysis, we found that marker rs2241880, a coding SNP (T300A), carries virtually all the disease risk exerted by the ATG16L1 locus. The ATG16L1 gene encodes a protein in the autophagosome pathway that processes intracellular bacteria. We found a statistically significant interaction with respect to Crohn disease risk between rs2241880 and the established CARD15 susceptibility variants (P = 0.039). Together with the lack of association between rs2241880 and ulcerative colitis (P > 0.4), these data suggest that the underlying biological process may be specific to Crohn disease.

URL for the Abstract:

http://www.nature.com/ng/journal/v39/n2/abs/ng1954.html

Categories,
Keywords:


HyperLinks / References / URLs:


Copyright Message:


Personal Comments:


Download
Access Level:

Public

Correlation

MPG Unit:

Max-Planck-Institut für Informatik



MPG Subunit:

Computational Biology and Applied Algorithmics

Appearance:

MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort


BibTeX Entry:

@ARTICLE{Albrecht2007a,
AUTHOR = {Hampe, Jochen and Franke, Andre and Rosenstiel, Philip and Till, Andreas and Teuber, Markus and Huse, Klaus and Albrecht, Mario and Mayr, Gabriele and De La Vega, Francisco M. and Briggs, Jason and G{\"u}nther, Simone and Prescott, Natalie J. and Onnie, Clive M. and H{\"a}sler, Robert and Sipos, Bence and F{\"o}lsch, Ulrich R. and Lengauer, Thomas and Platzer, Matthias and Mathew, Christopher G. and Krawczak, Michael and Schreiber, Stefan},
TITLE = {A genome-wide association scan of nonsynonymous {SNPs} identifies a susceptibility variant for {Crohn} disease in {ATG16L1}},
JOURNAL = {Nature Genetics},
YEAR = {2007},
NUMBER = {2},
VOLUME = {39},
PAGES = {207--211},
}


Entry last modified by Ruth Schneppen-Christmann, 02/28/2008
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Editor(s)
Ruth Schneppen-Christmann
Created
01/10/2007 10:09:22 AM
Revisions
11.
10.
9.
8.
7.
Editor(s)
Ruth Schneppen-Christmann
Uwe Brahm
Christine Kiesel
Mario Albrecht
Mario Albrecht
Edit Dates
24.01.2008 09:05:01
2007-07-10 15:35:40
01.07.2007 10:26:51
04/17/2007 07:01:25 PM
03/20/2007 07:11:23 PM
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