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Author, Editor

Author(s):

Emig, Dorothea
Blankenburg, Hagen
Ramírez, Fidel
Albrecht, Mario

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Editor(s):

Larson, Richard S

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Not MPII Editor(s):

Larson, Richard S

BibTeX cite key*:

Albrecht2012f

Title, Booktitle

Title*:

Functional characterization of human genes from exon expression and {RNA} interference results

Booktitle*:

Bioinformatics and Drug Discovery

Chapter:


Series:

Methods in Molecular Biolog

Language:

English

Publisher

Name*:

Humana Press

URL:

http://www.springerprotocols.com/

Address*:

New York, NY

Publication Type:


Vol, No, pp., Year

Volume:

910

Number:


Edition:

2. ed.

Pages*:

33-53

Month:


VG Wort Pages:


ISBN:

978-1-61779-964-8

Year*:

2012

Abstract, Links, ©

Note:


LaTeX Abstract:

Complex biological systems comprise a large number of interacting molecules. The identification and detailed characterization of the functions of the involved genes and proteins are crucial for modeling and understanding such systems. To interrogate the various cellular processes, high-throughput techniques such as the Affymetrix Exon Array or RNA interference (RNAi) screens are powerful experimental approaches for functional genomics. However, they typically yield long gene lists that require computational methods to further analyze and functionally annotate the experimental results and to gain more insight into important molecular interactions. Here, we focus on bioinformatics software tools for the functional interpretation of exon expression data to discover alternative splicing events and their impact on gene and protein architecture, molecular networks, and pathways. We additionally demonstrate how to explore large lists of candidate genes as they also result from RNAi screens. In particular, our exemplary application studies show how to analyze the function of human genes that play a major role in human stem cells or viral infections.

URL Abstract:

http://link.springer.com/protocol/10.1007%2F978-1-61779-965-5_3

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HyperLinks / References / URLs:


Personal Comments:


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Access Level:

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Correlation

MPG Unit:

Max-Planck-Institut für Informatik



MPG Subunit:

Computational Biology and Applied Algorithmics

Appearance:

MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort
BibTeX Entry:
@INBOOK{Albrecht2012f,
AUTHOR = {Emig, Dorothea and Blankenburg, Hagen and Ram{\'i}rez, Fidel and Albrecht, Mario},
EDITOR = {Larson, Richard S},
TITLE = {Functional characterization of human genes from exon expression and {RNA} interference results},
BOOKTITLE = {Bioinformatics and Drug Discovery},
PUBLISHER = {Humana Press},
YEAR = {2012},
VOLUME = {910},
EDITION = {2. ed.},
PAGES = {33--53},
SERIES = {Methods in Molecular Biolog},
ADDRESS = {New York, NY},
ISBN = {978-1-61779-964-8},
DOI = {10.1007/978-1-61779-965-5_3},
}


Entry last modified by Anja Becker, 03/13/2013
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Editor(s)
[Library]
Created
12/19/2012 12:06:06 PM
Revisions
4.
3.
2.
1.
0.
Editor(s)
Anja Becker
Anja Becker
Mario Albrecht
Mario Albrecht
Mario Albrecht
Edit Dates
13.03.2013 09:56:39
12.02.2013 13:44:12
01/05/2013 01:12:49 AM
01/05/2013 01:11:21 AM
12/19/2012 12:06:06 PM