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Author, Editor(s)

Author(s):

Lawyer, Glenn
Schülter, Eugen
Kaiser, Rolf
Reuter, Stefan
Oette, Mark
Lengauer, Thomas

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Not MPG Author(s):

Schülter, Eugen
Kaiser, Rolf
Reuter, Stefan
Oette, Mark

BibTeX cite key*:

Lawyer2012

Title

Title*:

Endogenous or exogenous spreading of HIV-1 in Nordrhein-Westfalen, Germany, investigated by phylodynamic analysis of the RESINA Study cohort


RESINA_publication.pdf (943.52 KB)

Journal

Journal Title*:

Medical Microbiology and Immunology

Journal's URL:

http://link.springer.com/journal/430

Download URL
for the article:

http://link.springer.com/article/10.1007%2Fs00430-011-0228-8

Language:

English

Publisher

Publisher's
Name:

Springer

Publisher's URL:

http:://www.springer.com

Publisher's
Address:

New York, NY

ISSN:

0300-8584

Vol, No, pp, Date

Volume*:

201

Number:

3

Publishing Date:

August 2012

Pages*:

259-269

Number of
VG Pages:


Page Start:

259

Page End:

269

Sequence Number:


DOI:

10.1007/s00430-011-0228-8

Note, Abstract, ©

Note:


(LaTeX) Abstract:

HIV’s genetic instability means that sequence similarity can illuminate the underlying transmission network. Previous application of such methods to samples from the United Kingdom has suggested that as many as 86% of UK infections arose outside of the country, a conclusion contrary to usual patterns of disease spread. We investigated transmission networks in the Resina cohort, a 2,747 member sample from Nordrhein-Westfalen, Germany, sequenced at therapy start. Transmission networks were determined by thresholding the pairwise genetic distance in the pol gene at 96.8% identity. At first blush the results concurred with the UK studies. Closer examination revealed four large and growing transmission networks that encompassed all major transmission groups. One of these formed a supercluster containing 71% of the sex with men (MSM) subjects when the network was thresholded at levels roughly equivalent to those used in the UK studies, though methodological differences suggest that this threshold may be too generous in the current data. Examination of the endo- versus exogenesis hypothesis by testing whether infections that were exogenous to Cologne or to Dusseldorf were endogenous to the greater region supported endogenous spread in MSM subjects and exogenous spread in the endemic transmission group. In intravenous drug using group subjects, it depended on viral strain, with subtype B sequences appearing to have origin exogenous to the Resina data, while non-B sequences (primarily subtype A) were almost completely endogenous to their local community. These results suggest that, at least in Germany, the question of endogenous versus exogenous linkages depends on subject group.

URL for the Abstract:


Categories,
Keywords:


HyperLinks / References / URLs:


Copyright Message:


Personal Comments:


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Access Level:

Public

Correlation

MPG Unit:

Max-Planck-Institut für Informatik



MPG Subunit:

Computational Biology and Applied Algorithmics

Appearance:

MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort


BibTeX Entry:

@ARTICLE{Lawyer2012,
AUTHOR = {Lawyer, Glenn and Sch{\"u}lter, Eugen and Kaiser, Rolf and Reuter, Stefan and Oette, Mark and Lengauer, Thomas},
TITLE = {Endogenous or exogenous spreading of {HIV-1} in {N}ordrhein-{W}estfalen, {G}ermany, investigated by phylodynamic analysis of the {RESINA} {S}tudy cohort},
JOURNAL = {Medical Microbiology and Immunology},
PUBLISHER = {Springer},
YEAR = {2012},
NUMBER = {3},
VOLUME = {201},
PAGES = {259--269},
ADDRESS = {New York, NY},
MONTH = {August},
ISBN = {0300-8584},
DOI = {10.1007/s00430-011-0228-8},
}


Entry last modified by Anja Becker, 03/13/2013
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Editor(s)
[Library]
Created
12/12/2012 12:49:57 PM
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Editor(s)
Anja Becker
Anja Becker
Glenn Lawyer
Glenn Lawyer
Glenn Lawyer
Edit Dates
13.03.2013 10:03:02
13.02.2013 10:51:10
02/04/2013 10:55:28 AM
01/28/2013 02:30:38 PM
10.01.2013 11:46:42
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