Journal Article
@Article
Artikel in Fachzeitschrift


Show entries of:

this year (2019) | last year (2018) | two years ago (2017) | Notes URL

Action:

login to update

Options:








Author, Editor(s)

Author(s):

Ketter, Ralf
Kim, Yoo-Jin
Storck, Simone
Rahnenführer, Jörg
Romeike, Bernd F.M.
Steudel, Wolf-Ingo
Zang, Klaus D.
Henn, Wolfram

dblp
dblp
dblp
dblp
dblp
dblp
dblp
dblp

Not MPG Author(s):

Ketter, Ralf
Kim, Yoo-Jin
Storck, Simone
Romeike, Bernd F.M.
Steudel, Wolf-Ingo
Zang, Klaus D.
Henn, Wolfram

BibTeX cite key*:

Rahnenfuehrer2007d

Title

Title*:

Hyperdiploidy defines a distinct cytogenetic entity of meningiomas

Journal

Journal Title*:

Journal of Neuro-Oncology

Journal's URL:


Download URL
for the article:

http://dx.doi.org/10.1007/s11060-006-9318-7

Language:

English

Publisher

Publisher's
Name:

Springer

Publisher's URL:


Publisher's
Address:

Berlin, Germany

ISSN:

0167-594X

Vol, No, pp, Date

Volume*:

83

Number:

2

Publishing Date:

2007

Pages*:

213-221

Number of
VG Pages:


Page Start:

213

Page End:

221

Sequence Number:


DOI:

10.1007/s11060-006-9318-7

Note, Abstract, ©

Note:


(LaTeX) Abstract:


Background  The most common chromosomal aberration found in meningiomas is monosomy 22. Progression and recurrence of meningiomas are usually associated with additional chromosome losses. Rarely, however, meningiomas have strongly hyperdiploid karyotypes with over 50 chromosomes; the objective of this study was to explore the cytogenetic and histopathologic patterns as well as the clinical significance of hyperdiploidy in meningiomas.
Methods  Within a series of 677 consecutive meningiomas, we identified a subgroup comprising 16 cases that display a strikingly uniform pattern of hyperdiploidy mostly without structural chromosome rearrangements, as shown by banding techniques and, in the single structurally aberrant case, spectral karyotyping.
Results  These meningiomas each have between 50 and 56 chromosomes, with trisomy 12 (14/16 cases), trisomy 20 (13/16 cases), trisomy 5 (12/16 cases), and trisomy 17 (10/16 cases). Histomorphologically, hyperdiploid meningiomas feature a heterogeneous phenotype. However, they are associated with a higher histological grade, and decreased expression of alkaline phosphatase as compared to meningiomas with typical karyotype. In two patients, recurrences were documented and three patients died of disease during the period of observation, indicating a worse prognosis of hyperdiploid than of cytogenetically typical meningiomas.
Conclusion  We conclude that hyperdiploidy constitutes a small but clinically relevant entity of biologically aggressive meningiomas, which are cytogenetically distinguishable from the majority of common-type meningiomas.

URL for the Abstract:

http://www.springerlink.com/content/q445711866144185/

Categories,
Keywords:

Meningioma - Cytogenetics - Hyperdiploidy - Progression

HyperLinks / References / URLs:


Copyright Message:


Personal Comments:


Download
Access Level:

Intranet

Correlation

MPG Unit:

Max-Planck-Institut für Informatik



MPG Subunit:

Computational Biology and Applied Algorithmics

Appearance:

MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort


BibTeX Entry:

@ARTICLE{Rahnenfuehrer2007d,
AUTHOR = {Ketter, Ralf and Kim, Yoo-Jin and Storck, Simone and Rahnenf{\"u}hrer, J{\"o}rg and Romeike, Bernd F.M. and Steudel, Wolf-Ingo and Zang, Klaus D. and Henn, Wolfram},
TITLE = {Hyperdiploidy defines a distinct cytogenetic entity of meningiomas},
JOURNAL = {Journal of Neuro-Oncology},
PUBLISHER = {Springer},
YEAR = {2007},
NUMBER = {2},
VOLUME = {83},
PAGES = {213--221},
ADDRESS = {Berlin, Germany},
ISBN = {0167-594X},
DOI = {10.1007/s11060-006-9318-7},
}


Entry last modified by Uwe Brahm, 02/28/2008
Show details for Edit History (please click the blue arrow to see the details)Edit History (please click the blue arrow to see the details)
Hide details for Edit History (please click the blue arrow to see the details)Edit History (please click the blue arrow to see the details)

Editor(s)
Jörg Rahnenführer
Created
02/15/2007 10:15:08 AM
Revisions
6.
5.
4.
3.
2.
Editor(s)
Uwe Brahm
Anja Becker
Uwe Brahm
Christine Kiesel
Christine Kiesel
Edit Dates
02/28/2008 04:17:19 PM
13.02.2008 15:38:57
2007-07-02 15:15:25
01.07.2007 10:41:47
15.02.2007 15:13:21