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Author, Editor(s)

Author(s):

Lehmann, Clara
Däumer, Martin
Bousaad, Ibrahim
Sing, Tobias
Beerenwinkel, Niko
Lengauer, Thomas
Schmeisser, Norbert
Wyen, Christoph
Fätkenheuer, Gerd
Kaiser, Rolf

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Not MPG Author(s):

Lehmann, Clara
Däumer, Martin
Bousaad, Ibrahim
Beerenwinkel, Niko
Schmeisser, Norbert
Wyen, Christoph
Fätkenheuer, Gerd
Kaiser, Rolf

BibTeX cite key*:

Lengauer2006g

Title

Title*:

Stable coreceptor usage of HIV in patients with ongoing treatment failure on HAART

Journal

Journal Title*:

Journal of Clinical Virology

Journal's URL:


Download URL
for the article:

http://dx.doi.org/10.1016/j.jcv.2006.08.008

Language:

English

Publisher

Publisher's
Name:

Elsevier

Publisher's URL:


Publisher's
Address:

Amsterdam, The Netherlands

ISSN:

1386-6532

Vol, No, pp, Date

Volume*:

37

Number:

4

Publishing Date:

2006

Pages*:

300-304

Number of
VG Pages:


Page Start:


Page End:


Sequence Number:


DOI:

10.1016/j.jcv.2006.08.008

Note, Abstract, ©

Note:


(LaTeX) Abstract:

Background
Disease progression in HIV infection has been associated with switch of viral coreceptor usage from CCR5 to CXCR4.
Objectives
To investigate the relationship between HIV-coreceptor tropism and clinical and virological outcome in 40 heavily pretreated patients over time.
Methods
Coreceptor phenotype was predicted after sequencing the V3 loop of the HIV glycoprotein 120.
Results
Coreceptor use was stable during observation time in 87% of patients, and CCR5 tropism was predominant. Viral mutations in the pol gene and clinical parameters were not predictive for coreceptor switching.
Conclusions
Even in patients with repeated HAART failure, CCR5 antagonists might be a valuable treatment option.

URL for the Abstract:

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VJV-4M04JGS-1&_user=43521&_coverDate=12%2F31%2F2006&_rdoc=14&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236104%232006%23999629995%23636612%23FLA%23display%23Volume)&_cdi=6104&_sort=d&_docanchor=&view=c&_ct=21&_acct=C000004638&_version=1&_urlVersion=0&_userid=43521&md5=e8eac48c07b446e01898a1c55540814c

Categories,
Keywords:

HIV, Chemokine receptors, Virus tropism, HAART failure, Resistance

HyperLinks / References / URLs:


Copyright Message:


Personal Comments:


Download
Access Level:

Public

Correlation

MPG Unit:




MPG Subunit:


Audience:

Expert

Appearance:

MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort


BibTeX Entry:

@ARTICLE{Lengauer2006g,
AUTHOR = {Lehmann, Clara and D{\"a}umer, Martin and Bousaad, Ibrahim and Sing, Tobias and Beerenwinkel, Niko and Lengauer, Thomas and Schmeisser, Norbert and Wyen, Christoph and F{\"a}tkenheuer, Gerd and Kaiser, Rolf},
TITLE = {Stable coreceptor usage of {HIV} in patients with ongoing treatment failure on {HAART}},
JOURNAL = {Journal of Clinical Virology},
PUBLISHER = {Elsevier},
YEAR = {2006},
NUMBER = {4},
VOLUME = {37},
PAGES = {300--304},
ADDRESS = {Amsterdam, The Netherlands},
ISBN = {1386-6532},
DOI = {10.1016/j.jcv.2006.08.008},
}


Entry last modified by Anja Becker, 02/13/2008
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Editor(s)
Ruth Schneppen-Christmann
Created
01/10/2007 10:01:17 AM
Revisions
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Editor(s)
Anja Becker
Ruth Schneppen-Christmann
Christine Kiesel
Ruth Schneppen-Christmann
Ruth Schneppen-Christmann
Edit Dates
13.02.2008 16:16:16
05.03.2007 08:20:39
20.02.2007 17:31:03
15.02.2007 10:16:02
10.01.2007 10:05:43
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