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Author, Editor(s)

Author(s):

Salamat-Miller, Nazila
Fang, Jianwen
Seidel, Christopher W.
Assenov, Yassen
Albrecht, Mario
Middaugh, C. Russell

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Not MPG Author(s):

Salamat-Miller, Nazila
Fang, Jianwen
Seidel, Christopher W.
Middaugh, C. Russell

BibTeX cite key*:

Albrecht2007b

Title

Title*:

A network-based analysis of polyanion-binding proteins utilizing human protein arrays

Journal

Journal Title*:

Journal of Biological Chemistry

Journal's URL:


Download URL
for the article:

http://dx.doi.org/10.1074/jbc.M610957200

Language:

English

Publisher

Publisher's
Name:

American Society for Biochemistry and Molecular Biology

Publisher's URL:


Publisher's
Address:

Bethesda, MD, USA

ISSN:

0021-9258

Vol, No, pp, Date

Volume*:

282

Number:

14

Publishing Date:

2007

Pages*:

10153-10163

Number of
VG Pages:


Page Start:


Page End:


Sequence Number:


DOI:

10.1074/jbc.M610957200

Note, Abstract, ©

Note:


(LaTeX) Abstract:

The existence of interactions between many cellular proteins and various polyanionic surfaces within a cell is now well established. The functional role of such interactions, however, remains to be clearly defined. The existence of protein arrays, with a large selection of different kinds of proteins, provides a way to better address a number of aspects of this question. We have therefore investigated the interaction between five cellular polyanions (actin, tubulin, heparin, heparan sulfate, and DNA) and 5,000 human proteins using protein microarrays in an attempt to better understand the functional nature of such interaction(s). We demonstrate that a large number of polyanion-binding proteins exist that contain multiple positively charged regions, are often disordered, are involved in phosphorylation processes, and appear to play a role in protein-protein interaction networks. Considering the crowded nature of cellular interiors, we propose that polyanion-binding proteins interact with a wide variety of polyanionic surfaces in cells in a functionally significant manner.

URL for the Abstract:

http://www.jbc.org/cgi/content/abstract/282/14/10153

Categories,
Keywords:


HyperLinks / References / URLs:


Copyright Message:


Personal Comments:


Download
Access Level:

Intranet

Correlation

MPG Unit:

Max-Planck-Institut für Informatik



MPG Subunit:

Computational Biology and Applied Algorithmics

Appearance:

MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort


BibTeX Entry:

@ARTICLE{Albrecht2007b,
AUTHOR = {Salamat-Miller, Nazila and Fang, Jianwen and Seidel, Christopher W. and Assenov, Yassen and Albrecht, Mario and Middaugh, C. Russell},
TITLE = {A network-based analysis of polyanion-binding proteins utilizing human protein arrays},
JOURNAL = {Journal of Biological Chemistry},
PUBLISHER = {American Society for Biochemistry and Molecular Biology},
YEAR = {2007},
NUMBER = {14},
VOLUME = {282},
PAGES = {10153--10163},
ADDRESS = {Bethesda, MD, USA},
ISBN = {0021-9258},
DOI = {10.1074/jbc.M610957200},
}


Entry last modified by Uwe Brahm, 02/28/2008
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Editor(s)
Mario Albrecht
Created
02/16/2007 12:29:56 AM
Revisions
12.
11.
10.
9.
8.
Editor(s)
Uwe Brahm
Anja Becker
Anja Becker
Anja Becker
Anja Becker
Edit Dates
02/28/2008 04:19:16 PM
14.02.2008 14:43:02
14.02.2008 14:35:58
14.02.2008 14:34:57
07/30/2007 05:43:26 PM