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Author, Editor(s)

Author(s):

Kono, Ken
Bozek, Kasia
Domingues, Francisco S.
Shioda, Tatsuo
Nakayama, Emi E.

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Not MPG Author(s):

Kono, Ken
Shioda, Tatsuo
Nakayama, Emi E.

BibTeX cite key*:

Kono2009

Title

Title*:

Impact of a single amino acid in the variable region 2 of the Old World monkey TRIM5alpha SPRY (B30.2) domain on anti-human immunodeficiency virus type 2 activity

Journal

Journal Title*:

Virology

Journal's URL:


Download URL
for the article:

http://dx.doi.org/10.1016/j.virol.2009.03.004

Language:

English

Publisher

Publisher's
Name:

Elsevier

Publisher's URL:


Publisher's
Address:


ISSN:

0042-6822

Vol, No, pp, Date

Volume*:

388

Number:

1

Publishing Date:

May 2009

Pages*:

160-168

Number of
VG Pages:


Page Start:


Page End:


Sequence Number:


DOI:

10.1016/j.virol.2009.03.004

Note, Abstract, ©

Note:


(LaTeX) Abstract:

Variable region 1 (V1) of the SPRY domain of TRIM5alpha is a major determinant for species-specific virus restriction in primates. We previously reported that a chimeric TRIM5alpha containing baboon V1 in the background of cynomolgus monkey TRIM5alpha showed potent anti-human immunodeficiency virus type 2 (HIV-2) activity. Since baboons are reportedly sensitive to HIV-2 infection, there was a discrepancy between the ability of baboon TRIM5alpha V1 to restrict HIV-2 and baboon sensitivity to HIV-2. In the study presented here, we examined the roles of V2 and V3 of the baboon TRIM5alpha SPRY domain in its anti-HIV-2 activity. A chimeric TRIM5alpha containing the entire baboon SPRY domain showed weak anti-HIV-2 activity. This attenuation of activity was caused by a single serine-to-proline substitution in baboon TRIM5alpha V2. These findings indicate that the combination of V1 with other variable regions of SPRY is important in anti-HIV-2 activity of primate TRIM5alpha.

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Access Level:

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Correlation

MPG Unit:

Max-Planck-Institut für Informatik



MPG Subunit:

Computational Biology and Applied Algorithmics

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MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort


BibTeX Entry:

@ARTICLE{Kono2009,
AUTHOR = {Kono, Ken and Bozek, Kasia and Domingues, Francisco S. and Shioda, Tatsuo and Nakayama, Emi E.},
TITLE = {Impact of a single amino acid in the variable region 2 of the Old World monkey {TRIM5alpha} {SPRY} ({B30.2}) domain on anti-human immunodeficiency virus type 2 activity},
JOURNAL = {Virology},
PUBLISHER = {Elsevier},
YEAR = {2009},
NUMBER = {1},
VOLUME = {388},
PAGES = {160--168},
MONTH = {May},
ISBN = {0042-6822},
DOI = {10.1016/j.virol.2009.03.004},
}


Entry last modified by Ruth Schneppen-Christmann, 01/13/2011
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Editor(s)
[Library]
Created
12/21/2009 01:32:28 PM
Revisions
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3.
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1.
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Editor(s)
Ruth Schneppen-Christmann
Anja Becker
Anja Becker
Anja Becker
Anja Becker
Edit Dates
13.01.2011 18:14:39
12.03.2010 10:21:00
11.03.2010 14:31:49
11.03.2010 14:31:16
12/21/2009 01:32:28 PM