Journal Article
@Article
Artikel in Fachzeitschrift


Show entries of:

this year (2019) | last year (2018) | two years ago (2017) | Notes URL

Action:

login to update

Options:




Library Locked Library locked




Author, Editor(s)

Author(s):

Lawyer, Glenn
Nesvåg, Ragnar
Varnäs, Katarina
Okugawa, Gaku
Agartz, Ingrid

dblp
dblp
dblp
dblp
dblp

Not MPG Author(s):

Lawyer, Glenn
Nesvåg, Ragnar
Varnäs, Katarina
Okugawa, Gaku
Agartz, Ingrid

BibTeX cite key*:

Lawyer2009_cerebellum

Title

Title*:

Grey and white matter proportional relationships in the cerebellar vermis altered in schizophrenia

Journal

Journal Title*:

Cerebellum

Journal's URL:


Download URL
for the article:

http://dx.doi.org/10.1007/s12311-008-0071-7

Language:

English

Publisher

Publisher's
Name:

Springer

Publisher's URL:


Publisher's
Address:

New York, NY

ISSN:

1473-4222

Vol, No, pp, Date

Volume*:

8

Number:

1

Publishing Date:

March 2009

Pages*:

52-60

Number of
VG Pages:


Page Start:

52

Page End:

60

Sequence Number:


DOI:

10.1007/s12311-008-0071-7

Note, Abstract, ©

Note:


(LaTeX) Abstract:

Magnetic resonance imaging studies frequently report abnormalities of the cerebellar vermis in schizophrenia, though with some discrepancies as to the nature and location of such abnormalities. Imaging studies typically investigate volumetric differences between groups. Yet substantial evidence supports the hypothesis that grey and white matter proportions in the mammalian brain are controlled by scaling relationships. If strong proportional relationships between grey and white matter tissue volumes are observed in the healthy vermis, then disturbances to these proportions might characterize vermian dysmorphology in schizophrenia. Measures of grey and white matter tissue volumes from three anatomical divisions of the vermis were obtained from 52 patients with chronic schizophrenia and 55 healthy controls. Cross-correlations of the tissue class volumes were computed for each subject group, controlling for age. The number of significant correlations in each group were compared. In addition, the grey/white matter ratio was computed within and across each vermian division. Differences in mean and variance were assessed using t and F tests. A false discovery rate of 0.05 controlled for multiple comparisons. Among controls, 11 of 15 correlations were significant. Among patients, eight of 15 correlations were significant. Five of the nine grey/white matter ratios had an increased mean in the patient group, and all of the variances were trend level or significantly increased in the patients. Tissue class volumes in the cerebellar vermis were strongly interrelated in controls. These relationships were disturbed in patients with schizophrenia.

URL for the Abstract:


Categories,
Keywords:


HyperLinks / References / URLs:


Copyright Message:


Personal Comments:


Download
Access Level:

Internal

Correlation

MPG Unit:

Max-Planck-Institut für Informatik



MPG Subunit:

Computational Biology and Applied Algorithmics

Appearance:

MPII WWW Server, MPII FTP Server, university publications list, working group publication list, Fachbeirat, VG Wort


BibTeX Entry:

@ARTICLE{Lawyer2009_cerebellum,
AUTHOR = {Lawyer, Glenn and Nesvåg, Ragnar and Varn{\"a}s, Katarina and Okugawa, Gaku and Agartz, Ingrid},
TITLE = {Grey and white matter proportional relationships in the cerebellar vermis altered in schizophrenia},
JOURNAL = {Cerebellum},
PUBLISHER = {Springer},
YEAR = {2009},
NUMBER = {1},
VOLUME = {8},
PAGES = {52--60},
ADDRESS = {New York, NY},
MONTH = {March},
ISBN = {1473-4222},
DOI = {10.1007/s12311-008-0071-7},
}


Entry last modified by Anja Becker, 03/11/2010
Show details for Edit History (please click the blue arrow to see the details)Edit History (please click the blue arrow to see the details)
Hide details for Edit History (please click the blue arrow to see the details)Edit History (please click the blue arrow to see the details)

Editor(s)
[Library]
Created
01/12/2010 10:03:52 AM
Revisions
2.
1.
0.

Editor(s)
Anja Becker
Anja Becker
Glenn Lawyer

Edit Dates
11.03.2010 14:39:06
11.03.2010 14:38:31
01/12/2010 10:03:52 AM