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Author, Editor(s)

Author(s):

Simmer, Femke
Brinkman, Arie B.
Assenov, Yassen
Matarese, Filomena
Kaan, Anita
Sabatino, Lina
Villanueva, Alberto
Huertas, Dori
Esteller, Manel
Lengauer, Thomas
Bock, Christoph
Colantuoni, Vittorio
Altucci, Lucia
Stunnenberg, Henk G.

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Not MPG Author(s):

Simmer, Femke
Brinkman, Arie B.
Matarese, Filomena
Kaan, Anita
Sabatino, Lina
Villanueva, Alberto
Huertas, Dori
Esteller, Manel
Colantuoni, Vittorio
Altucci, Lucia
Stunnenberg, Henk G.

BibTeX cite key*:

Simmer2012

Title

Title*:

Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues

Journal

Journal Title*:

Epigenetics

Journal's URL:

http://www.landesbioscience.com/journals/epigenetics/

Download URL
for the article:

http://www.landesbioscience.com/journals/epigenetics/2012EPI0255R.pdf

Language:

English

Publisher

Publisher's
Name:

Landes Bioscience

Publisher's URL:

http://www.landesbioscience.com/

Publisher's
Address:

Austin, USA

ISSN:

1559-2308

Vol, No, pp, Date

Volume*:

7

Number:

12

Publishing Date:

December 2012

Pages*:

1355-1367

Number of
VG Pages:


Page Start:

1355

Page End:

1367

Sequence Number:


DOI:

10.4161/epi.22562

Note, Abstract, ©

Note:


(LaTeX) Abstract:

aberrant DNa methylation often occurs in colorectal cancer (cRc). In our study we applied a genome-wide DNa methylation analysis approach, Methylcap-seq, to map the differentially methylated regions (DMRs) in 24 tumors and matched normal colon samples. In total, 2687 frequently hypermethylated and 468 frequently hypomethylated regions were identified, which include potential biomarkers for cRc diagnosis. hypermethylation in the tumor samples was enriched at cpG islands and gene promoters, while hypomethylation was distributed throughout the genome. Using epigenetic data from human embryonic stem cells, we show that frequently hypermethylated regions coincide with bivalent loci in human embryonic stem cells. DNa methylation is commonly thought to lead to gene silencing; however, integration of publically available gene expression data indicates that 75% of the frequently hypermethylated genes were most likely already lowly or not expressed in normal tissue. collectively, our study provides genome-wide DNa methylation maps of cRc, comprehensive lists of DMRs, and gives insights into the role of aberrant DNa methylation in cRc formation.

URL for the Abstract:

http://www.landesbioscience.com/journals/epigenetics/article/22562/?nocache=57780222

Categories,
Keywords:

bioinformatics, epigenetics

HyperLinks / References / URLs:


Copyright Message:


Personal Comments:


Download
Access Level:

Internal

Correlation

MPG Unit:

Max-Planck-Institut für Informatik



MPG Subunit:

Computational Biology and Applied Algorithmics

Appearance:

MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort


BibTeX Entry:

@ARTICLE{Simmer2012,
AUTHOR = {Simmer, Femke and Brinkman, Arie B. and Assenov, Yassen and Matarese, Filomena and Kaan, Anita and Sabatino, Lina and Villanueva, Alberto and Huertas, Dori and Esteller, Manel and Lengauer, Thomas and Bock, Christoph and Colantuoni, Vittorio and Altucci, Lucia and Stunnenberg, Henk G.},
TITLE = {Comparative genome-wide {DNA} methylation analysis of colorectal tumor and matched normal tissues},
JOURNAL = {Epigenetics},
PUBLISHER = {Landes Bioscience},
YEAR = {2012},
NUMBER = {12},
VOLUME = {7},
PAGES = {1355--1367},
ADDRESS = {Austin, USA},
MONTH = {December},
ISBN = {1559-2308},
DOI = {10.4161/epi.22562},
}


Entry last modified by Anja Becker, 12/13/2013
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Editor(s)
[Library]
Created
12/14/2012 05:31:55 PM
Revisions
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Editor(s)
Anja Becker
Anja Becker
Ruth Schneppen-Christmann
Ruth Schneppen-Christmann
Ruth Schneppen-Christmann
Edit Dates
13.12.2013 09:48:31
14.02.2013 10:48:34
05.02.2013 16:23:15
10.01.2013 11:37:43
21.12.2012 08:36:49