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MPI-INF D3 Publications :: Thesis :: Feuerbach, Lars

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Thesis - Master's thesis | @MastersThesis | Masterarbeit

Author(s)*:Feuerbach, Lars
BibTeX citekey*:Feuerbach2007

Title, School
Title*:Towards Comparative Epigenomics: A Pilot Study on DNA Methylation of CpG Islands on Human Chromosome 21
School:Universität des Saarlandes
Type of Thesis*:Master's thesis

Note, Abstract, Copyright
LaTeX Abstract:Over the last year the research on epigenetics has been intensified, as the

involvement of epigenetic mechanisms in human diseases has become evident.
With the generation of the first genome-wide datasets, the demand for appropriate
tools for their automated analysis begins to form. During the same period an
exponential growth of public available genome assemblies, has been triggered by
the development and spread of efficient DNA sequencing technologies. In
consequence of this situation a new scientific discipline is forming, for which the
term “comparative epigenomics” can be coined.

In this thesis a novel computational pipeline is presented, which enables the in
silico analysis of the evolutionary development of large scale datasets of genomic
regions. In a pilot study on datasets of CpG islands on human chromosome 21, this
pipeline is used to study the conservation of the DNA sequence, DNA structure,
DNA base composition and of putative epigenetic footprints of DNA methylation
in homologous regions in genome assemblies of 17 vertebrate species.
Furthermore, recent machine learning approaches are applied to investigate in how
far computational methods for the prediction of the methylation status of CpG
islands can be enhanced, by information from the comparative epigenomics field.

Keywords:Epigenetics, CpG islands, Epigenomics, DNA Methylation
Download Access Level:Internal

Referees, Status, Dates
1. Referee:Prof. Dr. Thomas Lengauer, Ph.D.
2. Referee:Prof. Dr. Jörn Walter
Date Kolloquium:10 December 2007

MPG Unit:Max-Planck-Institut für Informatik
MPG Subunit:Computational Biology and Applied Algorithmics
Audience:experts only
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BibTeX Entry:
AUTHOR = {Feuerbach, Lars},
TITLE = {Towards Comparative Epigenomics: A Pilot Study on DNA Methylation of CpG Islands on Human Chromosome 21},
SCHOOL = {Universit{\"a}t des Saarlandes},
YEAR = {2007},
TYPE = {Master's thesis}
MONTH = {September},

Entry last modified by Lars Feuerbach, 07/22/2014
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03/10/2009 10:46:04 AM

Lars Feuerbach
Lars Feuerbach

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03/10/2009 04:36:12 PM
03/10/2009 10:46:04 AM