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Author, Editor(s)

Author(s):

Svicher, Valentina
Cento, Valeria
Salpini, Romina
Mercurio, Fabio
Fraune, Maria
Beggel, Bastian
Han, Yue
Gori, Caterina
Wittkop, Linda
Bertoli, Ada
Micheli, Valeria
Gubertini, Guido
Longo, Roberta
Romano, Sara
Visca, Michela
Gallinaro, Valentina
Marino, Nicoletta
Mazzotta, Francesco
De Sanctis, Giuseppe Maria
Fleury, Hervè
Trimoulet, Pascale
Angelico, Mario
Cappiello, Giuseppina
Zhang, Xin Xin
Verheyen, Jens
Ceccherini-Silberstein, Francesca
Perno, Carlo Federico

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Not MPG Author(s):

Svicher, Valentina
Cento, Valeria
Salpini, Romina
Mercurio, Fabio
Fraune, Maria
Han, Yue
Gori, Caterina
Wittkop, Linda
Bertoli, Ada
Micheli, Valeria
Gubertini, Guido
Longo, Roberta
Romano, Sara
Visca, Michela
Gallinaro, Valentina
Marino, Nicoletta
Mazzotta, Francesco
De Sanctis, Giuseppe Maria
Fleury, Hervè
Trimoulet, Pascale
Angelico, Mario
Cappiello, Giuseppina
Zhang, Xin Xin
Verheyen, Jens
Ceccherini-Silberstein, Francesca
Perno, Carlo Federico

BibTeX cite key*:

Svicher2011

Title

Title*:

Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development

Journal

Journal Title*:

Digestive and Liver Disease

Journal's URL:

http://www.elsevier.com/locate/dld

Download URL
for the article:

http://dx.doi.org/10.1016/j.dld.2011.07.002

Language:

English

Publisher

Publisher's
Name:

Elsevier

Publisher's URL:

http://www.elsevier.com

Publisher's
Address:

Amsterdam

ISSN:

1590-8658

Vol, No, pp, Date

Volume*:

43

Number:

12

Publishing Date:

December 2011

Pages*:

975-983

Number of
VG Pages:


Page Start:

975

Page End:

983

Sequence Number:


DOI:

10.1016/j.dld.2011.07.002

Note, Abstract, ©

Note:


(LaTeX) Abstract:

Background:

Impact of hepatitis B virus genetic barrier, defined as the number and type of nucleotide
substitutions required to overcome drug/immune selective pressure, on drug-resistance/immune-escape
development is unknown.

Methods:

Genetic barrier was calculated according to Van de Vijver (2006) in 3482 hepatitis B virusreverse transcriptase/HBV surface antigen sequences from 555 drug-naïve patients and 2927 antiviraltreated patients infected with hepatitis B virus genotypes A-G.

Results:

Despite high natural variability, genetic barrier for drug-resistance development is identical amongst hepatitis B virus genotypes, but varies according to drug-resistance mutation type. Highest genetic barrier is found for secondary/compensatory mutations (e.g. rtL80I/V–rtL180M–rtV173L),
whilst most primary mutations (including rtM204V–rtA181T/V–rtI169T–rtA194T) are associated with
low genetic barrier. An exception is rtM204I, which can derive from a transition or a transversion. Genotypes A and G are more prone to develop immune/diagnostic-escape mutations sT114R and sG130N.
Vaccine-escape associated sT131N-mutation is a natural polymorphism in both A and G genotypes.

Conclusion:

Genetic barrier and reverse transcriptase/HBV surface antigen overlapping can synergistically
influence hepatitis B virus drug-resistance/immune-escape development. The different immune-escape
potential of specific hepatitis B virus genotypes could have important clinical consequences in terms of
disease progression, vaccine strategies and correct HBV surface antigen detection.

URL for the Abstract:


Categories,
Keywords:

hbv, hepatitis B, drug resistance, lamivudine, mutations

HyperLinks / References / URLs:


Copyright Message:


Personal Comments:


Download
Access Level:

Internal

Correlation

MPG Unit:

Max-Planck-Institut für Informatik



MPG Subunit:

Computational Biology and Applied Algorithmics

Appearance:

MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort


BibTeX Entry:

@ARTICLE{Svicher2011,
AUTHOR = {Svicher, Valentina and Cento, Valeria and Salpini, Romina and Mercurio, Fabio and Fraune, Maria and Beggel, Bastian and Han, Yue and Gori, Caterina and Wittkop, Linda and Bertoli, Ada and Micheli, Valeria and Gubertini, Guido and Longo, Roberta and Romano, Sara and Visca, Michela and Gallinaro, Valentina and Marino, Nicoletta and Mazzotta, Francesco and De Sanctis, Giuseppe Maria and Fleury, Herv{\`e} and Trimoulet, Pascale and Angelico, Mario and Cappiello, Giuseppina and Zhang, Xin Xin and Verheyen, Jens and Ceccherini-Silberstein, Francesca and Perno, Carlo Federico},
TITLE = {Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development},
JOURNAL = {Digestive and Liver Disease},
PUBLISHER = {Elsevier},
YEAR = {2011},
NUMBER = {12},
VOLUME = {43},
PAGES = {975--983},
ADDRESS = {Amsterdam},
MONTH = {December},
ISBN = {1590-8658},
DOI = {10.1016/j.dld.2011.07.002},
}


Entry last modified by Anja Becker, 02/28/2012
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Editor(s)
[Library]
Created
12/12/2011 02:01:09 PM
Revision
1.
0.


Editor
Anja Becker
Bastian Beggel


Edit Date
28.02.2012 10:50:14
12.12.2011 14:01:09