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MPI-INF D3 Publications :: Thesis :: Reuter, Kerstin

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Thesis - Bachelor thesis | | Bachelorarbeit

Author(s)*:Reuter, Kerstin
BibTeX citekey*:Reuter2011

Title, School
Title*:Estimating and Using the Uncertainty in the Phenotypic Resistance Assay of the Hepatitis B Virus to Improve {IC-50} Prediction from Genotype
School:Universität des Saarlandes
Type of Thesis*:Bachelor thesis

Publishers Name:Universität des Saarlandes
Publishers Address:Saarbrücken

Note, Abstract, Copyright
LaTeX Abstract:Hepatitis B is one of the most frequent infectious diseases worldwide. Thus improvement

of therapy is an active area of research. Since the hepatitis B virus can adapt to
treatment in terms of resistance mutations, therapeutic approaches often fail. With
computational support and statistical learning methods, it is possible to adjust therapy
according to the underlying virus. In consequence, an improvement of therapy is
enabled due to individual treatment.
In this thesis, an approach to predict the resistance from genome sequence is presented.
Resistance is de ned in terms of viral IC-50 concentration. A special feature described
is the usage of sample speci c weights based on the precision of the phenotypic assay.
These weights are meant to overcome a distortion of prediction results caused by
experimental measurement errors. For this purpose, the LASSO and linear support
vector machines were trained with 367 hepatitis B clones treated with four approved
antiviral drugs. Using uncertainty estimates, it was possible to moderately improve
prediction of the IC50 value from genotype for two out of four drugs.
In summary, this thesis provides a recent approach to support individual treatment
by improving prediction of the IC-50 value from viral genotype using sample speci c

Keywords:hbv, resistance, phenotype, genotype
Download Access Level:Internal

Referees, Status, Dates
Date Kolloquium:13 February 2012

MPG Unit:Max-Planck-Institut für Informatik
MPG Subunit:Computational Biology and Applied Algorithmics
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BibTeX Entry:
AUTHOR = {Reuter, Kerstin},
TITLE = {Estimating and Using the Uncertainty in the Phenotypic Resistance Assay of the Hepatitis B Virus to Improve {IC-50} Prediction from Genotype},
PUBLISHER = {Universität des Saarlandes},
SCHOOL = {Universit{\"a}t des Saarlandes},
YEAR = {2011},
TYPE = {Bachelor thesis}
ADDRESS = {Saarbr{\"u}cken},
MONTH = {September},

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02/13/2012 02:57:27 PM

Anja Becker
Anja Becker
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