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Author, Editor(s)

Author(s):

Tress, Michael L.
Martelli, Pier L.
Frankish, Adam
Reeves, Gabrielle A.
Wesselink, Jan J.
Yeats, Corin
Ólason, Páll Í.
Albrecht, Mario
Hegyi, Hedi
Giorgetti, Alejandro
Raimondo, Domenico
Lagarde, Julien
Laskowski, Roman A.
López, Gonzalo
Sadowski, Michael I.
Watson, James D.
Fariselli, Piero
Rossi, Ivan
Nagy, Alinda
Kai, Wang
Størling, Zenia
Orsini, Massimiliano
Assenov, Yassen
Blankenburg, Hagen
Huthmacher, Carola
Ramírez, Fidel
Schlicker, Andreas
Denoued, France
Jones, Phil
Kerrien, Samuel
Orchard, Sandra
Antonarakis, Stylianos E.
Reymond, Alexandre
Birney, Ewan
Brunak, Søren
Casadio, Rita
Guigo, Roderic
Harrow, Jennifer
Hermjakob, Henning
Jones, David T.
Lengauer, Thomas
Orengo, Christine A.
Patthy, László
Thornton, Janet M.
Tramontano, Anna
Valencia, Alfonso

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Not MPG Author(s):

Tress, Michael L.
Martelli, Pier L.
Frankish, Adam
Reeves, Gabrielle A.
Wesselink, Jan J.
Yeats, Corin
Ólason, Páll Í.
Hegyi, Hedi
Giorgetti, Alejandro
Raimondo, Domenico
Lagarde, Julien
Laskowski, Roman A.
López, Gonzalo
Sadowski, Michael I.
Watson, James D.
Fariselli, Piero
Rossi, Ivan
Nagy, Alinda
Kai, Wang
Størling, Zenia
Orsini, Massimiliano
Denoued, France
Jones, Phil
Kerrien, Samuel
Orchard, Sandra
Antonarakis, Stylianos E.
Reymond, Alexandre
Birney, Ewan
Brunak, Søren
Casadio, Rita
Guigo, Roderic
Harrow, Jennifer
Hermjakob, Henning
Jones, David T.
Orengo, Christine A.
Patthy, László
Thornton, Janet M.
Tramontano, Anna
Valencia, Alfonso

BibTeX cite key*:

Albrecht2007c

Title

Title*:

The implications of alternative splicing in the ENCODE protein complement

Journal

Journal Title*:

Proceedings of the National Academy of Sciences

Journal's URL:

http://www.pnas.org/

Download URL
for the article:

http://dx.doi.org/10.1073/pnas.0700800104

Language:

English

Publisher

Publisher's
Name:

National Academy of Sciences

Publisher's URL:


Publisher's
Address:


ISSN:

0027-8424

Vol, No, pp, Date

Volume*:

104

Number:

13

Publishing Date:

2007

Pages*:

5495-5500

Number of
VG Pages:


Page Start:


Page End:


Sequence Number:


DOI:

10.1073/pnas.0700800104

Note, Abstract, ©

Note:


(LaTeX) Abstract:

Alternative premessenger RNA splicing enables genes to generate more than one gene product. Splicing events that occur within protein coding regions have the potential to alter the biological function of the expressed protein and even to create new protein functions. Alternative splicing has been suggested as one explanation for the discrepancy between the number of human genes and functional complexity. Here, we carry out a detailed study of the alternatively spliced gene products annotated in the ENCODE pilot project. We find that alternative splicing in human genes is more frequent than has commonly been suggested, and we demonstrate that many of the potential alternative gene products will have markedly different structure and function from their constitutively spliced counterparts. For the vast majority of these alternative isoforms, little evidence exists to suggest they have a role as functional proteins, and it seems unlikely that the spectrum of conventional enzymatic or structural functions can be substantially extended through alternative splicing.

URL for the Abstract:

http://www.pnas.org/cgi/content/abstract/0700800104v1

Categories,
Keywords:


HyperLinks / References / URLs:


Copyright Message:


Personal Comments:


Download
Access Level:

Intranet

Correlation

MPG Unit:

Max-Planck-Institut für Informatik



MPG Subunit:

Computational Biology and Applied Algorithmics

Appearance:

MPII WWW Server, MPII FTP Server, MPG publications list, university publications list, working group publication list, Fachbeirat, VG Wort


BibTeX Entry:

@ARTICLE{Albrecht2007c,
AUTHOR = {Tress, Michael L. and Martelli, Pier L. and Frankish, Adam and Reeves, Gabrielle A. and Wesselink, Jan J. and Yeats, Corin and {\'O}lason, P{\'a}ll Í. and Albrecht, Mario and Hegyi, Hedi and Giorgetti, Alejandro and Raimondo, Domenico and Lagarde, Julien and Laskowski, Roman A. and L{\"o}pez, Gonzalo and Sadowski, Michael I. and Watson, James D. and Fariselli, Piero and Rossi, Ivan and Nagy, Alinda and Kai, Wang and Størling, Zenia and Orsini, Massimiliano and Assenov, Yassen and Blankenburg, Hagen and Huthmacher, Carola and Ram{\'i}rez, Fidel and Schlicker, Andreas and Denoued, France and Jones, Phil and Kerrien, Samuel and Orchard, Sandra and Antonarakis, Stylianos E. and Reymond, Alexandre and Birney, Ewan and Brunak, Søren and Casadio, Rita and Guigo, Roderic and Harrow, Jennifer and Hermjakob, Henning and Jones, David T. and Lengauer, Thomas and Orengo, Christine A. and Patthy, L{\'a}szl{\"o} and Thornton, Janet M. and Tramontano, Anna and Valencia, Alfonso},
TITLE = {The implications of alternative splicing in the {ENCODE} protein complement},
JOURNAL = {Proceedings of the National Academy of Sciences},
PUBLISHER = {National Academy of Sciences},
YEAR = {2007},
NUMBER = {13},
VOLUME = {104},
PAGES = {5495--5500},
ISBN = {0027-8424},
DOI = {10.1073/pnas.0700800104},
}


Entry last modified by Uwe Brahm, 03/25/2009
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Editor(s)
Fidel Ramirez
Created
03/20/2007 11:54:40 AM
Revisions
13.
12.
11.
10.
9.
Editor(s)
Uwe Brahm
Uwe Brahm
Anja Becker
Uwe Brahm
Uwe Brahm
Edit Dates
2009-03-25 18:34:42
02/28/2008 03:34:17 PM
20.02.2008 16:12:06
2007-07-11 10:42:07
03.07.2007 15:56:28