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MPI-INF D3 Publications :: Thesis :: Bastys, Tomas

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Thesis - Master's thesis | @MastersThesis | Masterarbeit

Author(s)*:Bastys, Tomas
BibTeX citekey*:Bastys2012

Title, School
Title*:{MAP} Kinase Docking Motifs in {HIV} Proteins
School:Universität des Saarlandes
Type of Thesis*:Master's thesis

Note, Abstract, Copyright
LaTeX Abstract:After 30 years of research, acquired immunodeficiency syndrome (AIDS) is still considered a pandemic and has no cure. Human immunodeficiency virus (HIV), which causes the disease, depends on the cellular protein machinery to replicate in the host cells. It has been suggested by different studies to employ mitogen-activated protein kinases (MAPKs), enzyme active in cell signalling, among other proteins. For its target recognition, MAPKs use a site on their surface separate from their active site, which recognises and docks with short linear motifs. This is a promising lead for targeting with drugs to inhibit HIV replication.

In this work the presence of such motifs was investigated in HIV proteins. Identified motifs were evaluated statistically. Afterwords selected candidates were modelled in complex with MAPK and docked. Additionally, the conservation of such motifs in HIV protein sequences was analysed to gain insight into evolution of MAPK docking motifs in HIV.

Download Access Level:Internal

Referees, Status, Dates
1. Referee:Dr. Olga Kalinina
2. Referee:Prof. Dr. Volkhard Helms
Supervisor:Dr. Olga Kalinina
Date Kolloquium:13 November 2012

MPG Unit:Max-Planck-Institut für Informatik
MPG Subunit:Computational Biology and Applied Algorithmics
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BibTeX Entry:
AUTHOR = {Bastys, Tomas},
TITLE = {{MAP} Kinase Docking Motifs in {HIV} Proteins},
SCHOOL = {Universit{\"a}t des Saarlandes},
YEAR = {2012},
TYPE = {Master's thesis}
PAGES = {96},
MONTH = {November},

Entry last modified by Anja Becker, 02/14/2013
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01/17/2013 02:27:04 PM

Anja Becker
Tomas Bastys

Edit Date
14.02.2013 11:31:16
01/17/2013 02:27:04 PM