Campus Event Calendar
Event Entry
What and Who
Protein Structure Comparison - a Continuous Problem in Structural Biology
Prof. Peter Lackner
University of Salzburg
Talk
AG 1, AG 2, AG 3, AG 4, AG 5
MPI Audience
Note: We use this to send email in the morning.
Date, Time and Location
Thursday, 2 December 2004
10:30
-- Not specified --
46.1 - MPII
021
Saarbrücken
Abstract
Comparing protein structures is a long standing problem in protein
science. A general solution is still missing. The current solutions
are either optimized for a certain structural aspect or a specific
application. An ideal method should be able to capture the different
types of structure similarity, should be fast enough to keep pace with
the rapidly growing structure databases and should deliver biological
meaningful alignments.
We give an overview of the basic problems. We analyze several methods
for how near they come to an ideal method and where they fail. Then we
introduce a distance based method, which aims to be fast enough to
perform database searches on a standard PC hardware but also delivers
alignments.
science. A general solution is still missing. The current solutions
are either optimized for a certain structural aspect or a specific
application. An ideal method should be able to capture the different
types of structure similarity, should be fast enough to keep pace with
the rapidly growing structure databases and should deliver biological
meaningful alignments.
We give an overview of the basic problems. We analyze several methods
for how near they come to an ideal method and where they fail. Then we
introduce a distance based method, which aims to be fast enough to
perform database searches on a standard PC hardware but also delivers
alignments.
Contact
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Ruth Schneppen-Christmann, 12/01/2004 12:15 -- Created document.