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What and Who

EpiGRAPH: A Toolkit for (Epi-) Genomic Relationship Analysis and Prediction in Human

Konstantin Halachev
IMPRS
Talk
AG 1, AG 2, AG 3, AG 4, AG 5, SWS  
AG Audience
English

Date, Time and Location

Monday, 10 July 2006
08:30
330 Minutes
E1 4
024
Saarbrücken

Abstract

Five years ago, the human genome sequence was published, an important milestone towards understanding human biology. However, basic cell processes cannot be explained by the genome sequence alone. Instead, further layers of control such as the epigenome will be important for significant clinical and basic research advances.

A new research field in computational biology is currently emerging that is concerned with the analysis of functional information beyond the human genome sequence. Our goal is to provide biologists with a toolkit to navigate the large amounts of epigenetic data and to screen these data for biologically interesting associations. We developed a statistical learning toolkit that facilitates mapping of epigenetic data against the human genome, identifies areas of over- and underrepresentation, and finds significant correlations with DNA-related attributes.
EpiGRAPH is a prototype of a genome analysis tool that enables the user to analyze relationships between many attributes, and it provides a quick test whether a newly analyzed attribute can be efficiently predicted from already known attributes. Thereby, EpiGRAPH may significantly speed up the analysis of new types of genomic and epigenomic data.

Contact

Kerstin Kathy Meyer-Ross
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Jennifer Gerling, 07/05/2006 09:28
Jennifer Gerling, 06/26/2006 11:55 -- Created document.